Journal of Hard Tissue Biology
Online ISSN : 1880-828X
Print ISSN : 1341-7649
ISSN-L : 1341-7649
Original
Biomechanical Analysis of Poly Lactic-co-glycolic Acid Catheter Combined with Bone Marrow Mesenchymal Stem Cells and Extracellular Matrix Transplantation for Long Sciatic Nerve Defect Repair
Chengdong PiaoZhengwei LiJie DingZhigang Qin
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ジャーナル フリー

2018 年 27 巻 4 号 p. 327-332

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We aimed to study the biomechanical characteristics of sciatic nerve after transplantation with poly lactic-co-glycolic acid (PLGA) catheter combined with bone marrow mesenchymal stem cells (BMMSCs) and extracellular matrix (ECM) gel in rabbit model of sciatic nerve injury, so as to provide biomechanics and other basis for the clinical practice. The rabbit sciatic nerve injury model was used in this study. The rabbits with sciatic nerve injury received autologous nerve transplantation (ANT), PLGA catheter combined with BMMSCs transplantation and PLGA catheter combined with BMMSCs and ECM gel transplantation respectively and then correspondingly grouped into ANT group, PCBT group and PCBET group. Twenty-four weeks later, the sciatic nerves in each group were used for electrophysiological examination, histomorphological observation and tensile mechanical properties test. Amplitude (AMP) and motor nerve conduction velocity (MNCV) values of the sciatic nerves in PCBET group were remarkably higher than those in the PCBT group and ANT group with statistical significance (P<0.05). The tensile elastic limit stress, elastic limit strain, maximum stress and strain in PCBET group were all larger than those in the PCBT group and ANT group with a significant difference (P<0.05). PLGA catheter combined with BMMSCs or PLGA catheter combined with BMSCs and ECM gel can restore the elasticity and toughness of the injured sciatic nerve at some extent, and has obvious recovery effect on the function of the injured sciatic nerves.

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