A Comparison of Mesenchymal Stem Cells from Human Adipose Tissues by Resection and by Liposuction

抄録

Adipose-derived mesenchymal stem cells (ASCs) have showed advantages in the source of therapeutic cells because of their paracrine function, multi-differentiation capacity, and easy access. Liposuction is an appropriate and safe method for obtaining adipose tissue, but little investigation exists regarding the impact of liposuction on the basic characteristics of ASCs. In this study, human ASCs were successfully isolated from liposuction and resected fat tissue. ASCs obtained via liposuction (Lip-ASCs) exhibited indiscriminate signatures when directly compared with resected fat tissue (Res-ASCs), including morphology, immunophenotype, viability, proliferation, and multi-directional differentiation potential. The comparison of multifaceted characteristics indicated that liposuction is an effective method to obtain and isolate ASCs with high quality, which is suitable for applications in basic research and clinical therapy.