2025 年 34 巻 1 号 p. 23-28
Regenerative approaches improve the results of furcation treatment; however, unpredictable periodontal regeneration is still observed in Class III furcation defects. This study assessed the effects of premolars with Class III furcations treated with porous carbonate apatite (CA) and basic fibroblast growth factor (bFGF). Class III furcations were created in the pre-molars of four beagle dogs. The teeth were randomly assigned to one of three treatment groups: Group 1 (control), treated with scaling and root planing; Group 2 (CA), the same treatment as Group 1 plus porous CA; and Group 3 (FGF + CA), the same treatment as Group 2 plus 60 μg of bFGF. After a 10-week healing period, the third and fourth lower premolars were scanned using micro-focus X-ray computed tomography (CT), followed by routine histological processing and conventional staining (hematoxylin and eosin), azan staining, and TRAP staining. Micro-CT analysis indicated better regenerative results in FGF + CA, which showed greater mineralized tissue filling of the defects in comparison to the control and CA groups. A comparison between the control and FGF + CA groups showed that the new bone area was significantly higher in the FGF + CA group (P < 0.05). After the 10-week healing period, new bone area (%) was as follows: control, 17.58±2.98%, CA, 44.66±19.52% and FGF + CA, 69.22±7.94%. These results indicate that porous CA with bFGF may enhance the regenerative results in Class III furcation lesions.
