新規アフィニティーカラムによる創薬標的分子の同定

抄録

The identification of target proteins of bioactive compounds such as natural products, old medicines, pending compounds due to side effects, and so on, is now an interested theme in the post-Genome era. Affinity resins have been used for this purpose and exhibited some successful discoveries. However, it is not usually easy to identify them using traditional technology even now, especially for hydrophobic compounds such as orally active compounds. We have focused our efforts on developments of technologies for identification of them using affinity chromatography matrices bearing such compound. Our technologies including recent one that have been developed for these identifications will be presented with some successful examples.