Abstract
Isosorbide is one of drugs used for the treatment of patients with Meniere's disease, but there is often poor compliance due to its bitter taste. We recruited healthy volunteers to test whether isosorbide could be made more palatable by adding it to a beverage. The subjects frequently complained of a bitter taste when they took isosorbide alone. They documented that there was a significantly improved taste when they took isosorbide by adding it to orange juice, coca-cola oran ion-tonic beverage. However, they tended to document that there was an even worse taste when they took isosorbide after adding it to green tea. These results indicate that adding isosorbide to orange juice, coca-cola or an ion-tonic beverage may improve drug compliance.
