2018 Volume 64 Issue 6 Pages 215-222
We performed super-selective intraarterial injection chemotherapy combination radiation therapy (RADPLAT) by administering CDDP 100 mg/m2/session for advanced maxillary sinus cancer every week during the treatment course. We examined the histological curative effect in 25 cases treated from February 2011 to August 2017. There were no cases of a complete response according to an evaluation by RECIST with 40 Gy irradiation, but a partial response was noted in 23 cases, while stable disease and progressive disease were noted in one case each. As administering a full dose of radiation treatment (70 Gy) was deemed to be difficult, we performed surgery in all cases. Approximately half (n=13) of all cases were found to have Grade 3 disease according to the established criteria. In 1 Grade 1a case (T4a, intraarterial injection 4 times), we performed an additional 30 Gy of irradiation because the resected edge of the maxillary sinus rear wall showed positivity. No consistent tendency was noted in the association between the T classification, the number of intraarterial injections, the differentiation degree and the findings of the histological curative effect of the tumor. In addition, the evaluation by RECIST and the evaluation of the histological curative effect showed no particular correlation in these cases.
