A case of EBER-positive sphenoid sinus cancer successfully treated with radiochemotherapy

Abstract

We herein report a case of EBER-positive sphenoid sinus cancer successfully treated with radiochemotherapy. A 56-year-old man presented with various cranial nerve symptoms, such as unilateral deafness and ocular motility disorder, and was diagnosed by a biopsy under nasal endoscopy at our department. The lesion was an EBER-positive, non-keratinized squamous cell carcinoma, similar to nasopharyngeal carcinoma. The prognosis was judged to be good, and the patient's quality of life and function preservation were prioritized, so radiochemotherapy was selected. After performing radiotherapy with cisplatin, tegafur/gimeracil/oteracil oral treatment was performed as an additional treatment, and as a result, a complete response was achieved. Currently, although some neuropathy due to direct tumor infiltration or radiation injury remains, no recurrence or metastasis has been observed.