Abstract
Twenty cases of sensory-neural deafness such as acoustic trauma, streptomycin poisoning, Ménière's disease and some kinds of deafness whose geneses are unknown were treated with Adenosine in expectation of the cochlear vasodilatator effect of this drug.
Out of 20 cases, 35 ears of sensory-neural deafness were observed. 60 mg of the agent a day was given by mouth for several weeks.
The author evaluated the agent to be effective when the data indicated the improvement of hearing over 10 db in two of the three calculating methods employed as follows; the average of hearing loss in cases of 125, 500, 1000, 2000, 4000 and 8000 cps, the average of hearing loss in the speech range of frequencies (500, 1000 and 2000 cps) and the average of hearing loss in cases of 250, 1000 and 4000 cps.
Hearing loss was imploved in 6 out of 35 ears (17%) and tinnitus vanished or diminished in 8 out of 27 ears (29.6%).
This drug is comparatively effective for Ménière's disease, acoustic trauma and streptomycin poisoning.
