Cochlear blood volume in the guinea pig measured with Cr51 labelled red blood cells
1968 Volume 14 Issue 2 Pages 82-89
Details
1968 Volume 14 Issue 2 Pages 82-89
Cochlear blood volume using Cr51 abelled red blood cells was measured in the guinea pig. No data of blood volume in the various organs have been reported in the guinea pig, as far as the authors are aware, so values of these are also included(Table 1). Blood volume was derived from organ isotope content divided by isotope content per 1μl blood. Blood volume in the whole cochlea was calculated to be 1.35μl(Table 2)of which 85%was in the bony capsule and 15% (0.20μl)was in the inside of the cochlea and this 0.20μlwould contain 0.04μl of O2. JOHNSTONE (1967)has calculated the minimum O2 necessary for cochlear function as 0.025-0.1μl/min;therefore after stoPPing blood flow the oxygen should be consumed in 24 to 96 seconds. PERLMAN et al. reported that the survival times of cochlear microphonics(CM)and auditory action potentials (N1, N2) after occlusion of the artery were about 80 seconds, 40 seconds and 30 seconds respectively. Their results show good agreement with the present results.
