In 1939 the author discussed on the close relationship of hereditary deafness with Beriberi in V. Bi-deficiency. Consecutively the author gave his own opinion that the etiology of the perceptive deafness, especially in that of unknown causes, shoud be found in thiamine deficiency. Futhermore, even by the latent thiamine deficiency, it might disturb the next generation, and the possibility of the geneimpairing by nerve deafness was discussed. In the perceptive deafness of known etiology also the predisposed thiamine deficiency can play an important role as the developing factor of its outbreak. In 1948 TOMOMATSU found the positive Sawada's urinary reaction of pyruvic acid increase by 75% of nerve-deafness cases of unknown etiology.
This special condition is based upon alimentary situation of our nation, characterized by unbalanced carbohydrate rich diet which requires too much use of carboxylase, to some extent, I believed.
Acetylcholine is well known as a significant chemical substance necessary for sensorineural activity mechanism. It relates also to auditory perception in various portions. We know the existence of pseudo-cholinesterase in plasma and true cholinesterase in red cells. The content of cholinesterase in plasma of normal person has been measured undoubtedly as almost constant value to a certain degree until comparatively lately, however, what is interesting is that recently a fact was recognized in pharmacogenetics, there are few exceptional individuals of poor cholinesterase among normal persons. And it was reported that there exists inherent tendency by it.
Lately we measured the levels of cholinesterase of serum in 10 normal persons and on the other side that of 30 patients with sensori-neural deafness. The average enzymatic level of cholinesterase in perceptive deafness as 0.77±0.05, presented lower value than that of normal control group as 0.92±0.05. On the other hand the intimate relationship of cholinesterase with thiamine deficiency has been noted since MINz (1937) etc. The cholinesterase is an inhibitor of thiamine.
Thus the inherent enzymatic disorder will develop to a nerve-deafness of unknown cause with symmetrical flat audiograms, when they get an endogenous manifestation in their younger days.
The metabolic disorder by thalidomide embryopathy or by maternal rubella almost in the same way alter the organogenesis and can cause an abnormal pattern of enzyme activity.
Congenital distribution of the inner ear vessels may play a certain role as disposition former. Functional states of the inner ear vessels can be influenced by inheritable nature of the autonomic nervous system. These above-mentioned factors should be related in various ways to bear perceptive deafness. I should like to conclude the inheritable enzymatic disorder of the auditory organ may produce a recessive disposition to provoke the perceptive deafness.

View full abstract

Cochlear blood volume using Cr⁵¹ abelled red blood cells was measured in the guinea pig. No data of blood volume in the various organs have been reported in the guinea pig, as far as the authors are aware, so values of these are also included(Table 1). Blood volume was derived from organ isotope content divided by isotope content per 1μl blood. Blood volume in the whole cochlea was calculated to be 1.35μl(Table 2)of which 85%was in the bony capsule and 15% (0.20μl)was in the inside of the cochlea and this 0.20μlwould contain 0.04μl of O2. JOHNSTONE (1967)has calculated the minimum O₂ necessary for cochlear function as 0.025-0.1μl/min;therefore after stoPPing blood flow the oxygen should be consumed in 24 to 96 seconds. PERLMAN et al. reported that the survival times of cochlear microphonics(CM)and auditory action potentials (N₁, N₂) after occlusion of the artery were about 80 seconds, 40 seconds and 30 seconds respectively. Their results show good agreement with the present results.

View full abstract

Ein 11 jahriges Madchen, das seit 1 Jahr die beiderseitige Nasenverstopfung und die sanduhrartige Anschwellung des Nasendaches bekommen hatte, suchte unser Ambulatorium auf.
Rhinoskopisch war die linke Nasenhohle mit einem dunn rotlichen, glatten und harten Tumor vollkommen erftillt. Die Nasenscheidewand war wegen des Tumores nach rechts hochgradig verbogen.
Der Tumor wurde nach Denker vollstandig exstirpiert, der 71mm×62mm× 35mm groB war und 45g wog. Die Schnittflache war parenchymatos ohne Nekrosegewebe. Der exstirpierte Tumor war auch als ganzes mit dem Plattenepithel bedeckt und histologisch ein typisches Neurinom, obwohl das Probesttick vor der Operation als ein entztindliches Pseudotumor diagnostiziert wurde.

View full abstract

Im Zeitraum vom 1. Marz 1956 bis zum 31. Juli 1967 haben wir Verfasser 30 Falle von zystischen Erkrankungen des Oberkiefers behandelt.
Die Falle der postoperativen Wangenzyste (23 Falle, 77%) machen unter der Gesamtzahl der Falle 76.6% aus. Danach folgen die Falle von Nasenvorhofzyste (3 Falle, 10%), die Falle von follikularer Zahnzyste (2 Falle, 6.6%) und die Falle von Globulomaxillarzyste (2 Falle, 6.6%).
Die Verfasser haben auch tiber das Geschlecht und das Alter der Patienten, kranke Seite, die klinischen Symptome, die histologischen, biochemischen sowie bakteriologischen Befunde der Inhaltfltissigkeit und ebenso Ober die Behandlungsmethode Statistiken aufgestellt.

View full abstract

The laryngeal bilateral abductor paralysis of a girl, aged 17, who complained of stridor and dyspnea which seemed to occur just after her birth, was surgically treated by Woodman's method, with good results, viz. the disappearance of symptoms described above and the maintenance of relatively good voice.

View full abstract

Ménière's disease is usually treated conservatively. If the disease is, however, stubborn for conservative treatments it would be unavoidable to be treated surgically.
The author recently had a chance to perform chorda tympanectomy after ROSEN in such four cases. By this operation two patients were cured of attacks of vertigo and the remaining two got better.
The author preferred to perform the operation by retroauricular approach. By this route the author could succeed in performing the operation more easily and safely without injuring tympanic membranes even in the patients who had narrow external auditory canals.
From these experiences the author concludes as follows:
1. The chorda tympanectomy after ROSEN is certainly effective in some cases of stubborn Méière's disease.
2. By retroauricular approach this operation is considered to be performed more easily and safely even in the patient who has narrow external auditory canals.

View full abstract

Das Auftreten einer Mischgeschwulst im Bereich der Gaumentonsille ist verhältnismaBig selten. Wir Verfasser haben neulich Gelegenheit gehabt, zwei Fälle einer derartigen Mischgeschwulst der Tonsillengegend zu behandeln.
Beim 1. Fall handelte es sich um eine 39 jährige Frau, die seit einem Jahr eine schmerzlose Anschwellung lateral der rechten Gaumentonsille bemerkt hat. Der Tumor zeigte keine Empfindlichkeit gegen die ambulatorisch durchgefuhrte Co⁶⁰-Bestrahlung (5600 R).
Der 2. Patient, ein 39 jähriger Lehrer, hat auch seit einem Jähr einen schmerzlosen Tumor an derselben Stelle bemerkt. Er hat sich zweimal einer Punktion der Peritonsillargegend erfolglos unterzogen.
Die Diagnose der sogenannten Mischgeschwulst wurde in beiden Fallen erst festgestellt, als wir eine dicke weiBliche Kapsel submukös bestätigten und die Probestücke histologisch untersuchten. Histologisch war der Tumor in beiden Fällen das “pleomorphe Adenom”.
In beiden Fallen wurde die Exstirpation der Tumoren in Lokalanasthesie vom Munde aus ohne besondere Schwierigkeiten durchgefuhrt.

View full abstract

Many workers began to complain of dim hearing in an iron factory eight months after their employment. The factory was found to be in noisy circumstances of about115-135 phons.
The audiometric examinations were exercised onthose 13 workers and the other 50 who had worked in the other branches of the factory.
The intensity of the noise was 115dB SPL lmeter away from the noise source, and 105 dB SPL 10 meters away. The distribution pattern of the noise frequency had a peak in mid frequency range.
The pure-tone audiograms of these 13 workers showed bilateral symmetrical hearing. 10ss in all frequencies, and the audiograms of the other 50 workers showed a typical high-frequency hearing-loss. Some differences were observed in the grade of hearing-loss of these 13 cases, although they were employed on the same day. Three cases had 20-30 dB hearing-loss, five cases 40-50 dB, and four cases above 60 dB.
It was presumed that the intense noise for several monthes had caused such afull-frequency hearing-loss.

View full abstract

Vitamedin (compound of Vitamin Bi, B6 and B12), Verina CI\Tylidrin hydro- chloride) and Adetphos (Adenosine triphosphate) were administrated to 13 workers for 2 months. They had complained of dim hearing caused under the noisy circumstances of about 115-135 phons for about 8 months.
All cases showed remarkable recovery of hearing 1 month after the administ- ration of the drugs. The statistical examination proved that the results were reliable. Especially, hearing was much recovered in those who had had hearing-loss of above 60 dB in speech frequency area. In addition to the above drugs, they were administrated Biotinin (active Vitamin B1) intravenously and Decadron Nexamethazone) internally. And also they were arranged to work in the other less noisy branch of the factory.
Their audiograms showed that their hearing had the tendency of getting low when the administration of Biotinin and Decadron was ceased a month after the commencement of medical treatment.
It is suggested that these improvement of hearing was due to the versatility of the noise-induced disturbance of the inner ear in its early stages and that the administration of the drugs hastened the recovery.

View full abstract

The authors used “Cepharanthin” for the 90 cases who complained of tinnitus aurium; the 12 cases after tympanoplasty, 15 cases of combined deafness and 63cases of nerve deafness. Internally 3-6 mg tablets or powder of it was given to the patient a day and by injection 5-10mg of it.
The results were as follows:
1) Tinnitus was improved in 41.6% of the 12 cases after tympanoplasty, in 33.3%of the 15 cases accompained by combined deafness, and in 26.6% of the 63 cases suffering from nerve deafness.
2) It was more effective in tinnitus accompanied by conductive deafness than by nerve deafness.
3) Its injectional use was more effective than its internal use.

View full abstract