1978 Volume 24 Issue 4Supplement2 Pages 695-699
Quantitative analysis of serum amylase isozyme in diseases of the salivary glands was undertaken. The separation of serum amylase in its isozyme was carried out by electrophoresis using cellulose acetate membrane. The fractions stained with blue starch were measured quantitatively by densitometry. The following results were obtained:
1. An increase of S-type isozyme was found in cases with swelling of the parotid and/or submandibutar glands as well as in cases with sialolithiasis.
2. In cases of SjOgren's syndrome, the S-type isozyme decreased when the salivary gland function was impaired, but it was within normal limits in patients with xerostomia.
3. In cases of hyperamylasemia of unknown etiology, increased amylase was necessarily of the S-type. However, the origin of the excessive production was not believed to be the salivary glands.
