jibi to rinsho
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
Volume 24, Issue 4Supplement2
Displaying 1-27 of 27 articles from this issue
  • Takuya UEMURA, Yasuko ARAI, Chiga SHIMAZAKI, Reiko HATTORI
    1978 Volume 24 Issue 4Supplement2 Pages 559-565
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    To clarify the characteristics of eye-head coordination during active head movements, the responses of 10 normal subjects to 10°, 20°, 30°, 40° and 50° target presentations were analyzed quantitatively. The following results were obtained.
    1. With the increase of the target angle, the latency of the eye movement increased. On the other hand, that of the head movement decreased. Thus, difference between the latencies of head and eye movements decreased with increasing target angles, e. g. 139 msec at 10° and 50 msec at 40°.
    2. The risetimes of the eye and head movements increased with the target angle.
    3. The maximum velocity of the eye movement averaged 292°/sec at 10°, increased to 398°/sec at 20°, and remained unchanged thereafter. The maximum velocity of the head movement increased in proportion with the target angle (correlation coefficient r=0.65).
    4. The amplitude of the head movement at the time when the eye reached its maximum displacement increased with the target angle, e. g. the head moved through an average of 13% of the target angle at 50°. The sum of eye and head displacement, i. e. gaze, coincide with the target angle at the time of peak eye displacement. This fact indicated that the eye was perfectly fixed upon the target at the end of the eye saccade.
    5. At the final resting position, the amplitude of the gaze was exactly the same as the target angle with minimum variance. This proved the accuracy of the technique employed for the recording of eye and head movements.
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  • Masahiro TAKAHASHI, Takuya UEMURA, Yasuko ARAI, Chiga SHIMAZAKI, Takeh ...
    1978 Volume 24 Issue 4Supplement2 Pages 566-570
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    In order to study vestibular-visual interaction during active (voluntary) head movements, we devised a new test in which examinees turn their heads sinusoidally by 40° in time to a metronome. We set four different visual stimulus conditions as follows.
    1. Mental arithmetic in the dark. 2. Continuous visual fixation on a lamp placed on the wall. 3. Continuous visual fixation on a lamp moving with the head. [2 and 3:a) in light b) in dark (imagine a lamp)] 4. Continuous visual pursuit of the lamp on the wall through a mirror installed diagonally in front of the eyes.
    In a vestibular-visual coordinated situation (testing condition 2), all subjects could fix the eyes on the lamp on the wall whether it was switched on or off. However, as vestibular nystagmus becomes dominant in dyscoordinated conditions (vestibular-visual conflict, testing condition 3 and 4) even in light, especially during turns of high frequencies, visual fixation or pursuit is remarkably disturbed and inter-individual differences in these abilities become marked.
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  • Toyoji SODA, Toshihiko KATO, Shigeaki SHIRABE, Kimio SHIRAISHI
    1978 Volume 24 Issue 4Supplement2 Pages 571-583
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    The scalp distributions of human auditory evoked responses were studied by the method of the computerized display system. Early ( 0 to 10ms.) and middle (10 to 50ms.) latency responses were recorded on electrode locations of 10-20 system to binaural and monaural stimulation. The auditory evoked potentials obtained from each location were interpolated by means of the two-variable sampling function. Then the interpolated values were quantized to 11 levels and finally, the quantized values were printed out on line-printer as the scalp topography of the auditory evoked responses.
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  • Hidetaka TAKEDA
    1978 Volume 24 Issue 4Supplement2 Pages 584-593
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    Cell membranes have the most important function among the sensory cells receiving the energy of sound and light. They consist mainly of phospholipids and proteins. Experimentally, I found that these membrane materials are dissociated by sound and light. Of the phospholipids (lecithin and cephalin), lecithin had a larger electric potential by the dissociation than cephalin. And the stronger the energy of light, the more easily these membrane materials were apt to be dissociated in comparison with sound. Moreover, it is imagined that compared with Na+ and K+ solution (Ringer solution-perfect electrolyte solution) which is strong against energy and does not show almost any voltage change.
    1. phospholipids and protein solution which are comparatively weak against energy in spite of high molecular materials are dissociated by sound and light and produce potential (the first step of the excitation, that is, the action of sensor?).
    2. The sudden rise of potential is found by adding Ringer solution. But according to our experiments, we believe that Na+ and K+ do not change the energy of sound and light into electric energy, although they amplify the polarization potential of the solution.
    3. I suggest, taking into account the electron-microscopic structure of the hair cells, that the apical portion of these cells act as a “phototube” to light by showing the model with chemical materials.
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  • Junichiro NANDATE
    1978 Volume 24 Issue 4Supplement2 Pages 594-597
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    I emphasized that careful observation of the differences in hearing losses between both ears is more important for practical clinical use than detecting absolute hearing losses in patients with unilateral hearing losses.
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  • Hiroko ISHIZAWA
    1978 Volume 24 Issue 4Supplement2 Pages 598-604
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    The audiogram patterns of 64 deaf sibling pairs (128 patients), one of whom visited the Visual and Auditory Research Institute of Fukuoka Medical Association in the past five years and who could undergo audiometric tests were investigated. The following results were obtained.
    1. Most of the 29 pairs of congenital profound deafness, both of whom showed only residual hearing acuity in low tones, were found to have consancuineous parents.
    2. Relatively severe hearing loss was found in most of the patients. Nine of 10 pairs of whom both showed similar severity of hearing loss were cases of severe hearing loss. In these cases, the elder sibling usually showed more a profound hearing loss.
    3. Regarding the types of audiograms, gradual high tone loss and scale out were found frequently.
    4. Similarity of right and left audiograms was found in 69.9% of the patients.
    5. Two out of three pairs of identical twins showed similar audiogram types, but different severity of hearing loss.
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  • Taeko KOIBUCHI
    1978 Volume 24 Issue 4Supplement2 Pages 605-615
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    In order to ascertain the relationship between the intensity of stimulus and the magnitude of nystagmic response in caloric tests, I gavefive graded caloric stimulation of 30, 25, 20, 15 and 10° to 15 otologically normal adults. The parameters used were the maximum slow-phase eye velocity, maximumfrequency and durationof nystagmus. Quantitative analysis of these parameters resulted in the followingconclusions:
    1. The nystagmic response rose with increasing intensity of stimulation, i. e, 30°, 25°, 20°, 15°, 10°, for all of the three parameters. Correlation between stimulations and responses was most prominent in the maximum slow-phase eye velocity.
    2. Significant bilateral differences in the responses were observed in the three parameters at almost all stimulating temperatures. However, since there was no constant relationship among the parameters, this variance seemed to be caused by accidental factors.
    3. No definite correlation was found among the maximum slow-phase eye velocity, duration and maximum frequency of nystagmus. Therefore, these three factors should be examined for complete analysis of nystagmic response.
    4. Of thefivedifferent temperatures, combinations of two showing asignificant difference were selected by Welch's test. The greatest difference in nystagmic response was noted in the combination of 30° and10°. When 30° was eliminated to minimize the number of cases showing no response, the combination of 25 and 10 showed the greatest difference.
    5. Evaluation by the standard score method of the three parameters in the case of 25 and 10stimulations revealed that the ratio at which the values of weak and strong caloric stimulations were homogeneous was highest in the maximum slow-phase eye velocity.
    It was concluded that measurement of the maximum slow-phase eye velocity of nystagmus at 25 and10stimulations is most reliable for clinical investigation of the relationship between the intensity of-stimulus and the magnitude of response in the caloric test.
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  • Mitsuko ITOH
    1978 Volume 24 Issue 4Supplement2 Pages 616-629
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    In order to investigate imbalances of the autonomic nervous system in MENIERE's disease, the pupil size was measured in darkness after 10 minute's rest, in the light reaction test and with the application of mecholyl and/or epista solutions to the eyes of the patients and a control group. The pupil size was calculated by measuring its diameter on negative films which were taken with a specially-designed infrared-sensitive pupillograph. The following results were obtained.
    1. A difference in pupil size between the right and left eyes after 10 minute's rest in darkness was not observed even during definitive spells of MENIERE's disease.
    2. In the light reaction test, pupil size measured 0.5 and 2.5 seconds after flash stimulation resulted in no difference between the affected and unaffected sides in the patient group.
    3. With the application of 5% mecholyl solution to the eyes, miosis of more than 10% was found only in one out of 32 (3.1%) eyes in the control group. On the other hand, in cases of MENIERE's disease, five out of eight affected side's eyes showed significant miosis during definitive spells (62.5%), eight out of 16 (50%) during adjunctive spells and 15 out of 56 (26.8%) during the intervals between spells. The miosis on the affected side's eyes in the patients were found to be significantly high compared with those in the control group (P<0.01), whereas no difference was observed between the unaffected side's eyes and the control group (P>0.05).
    These findings suggest that imbalances in the autonomic nervous system on the affected side play a role in the etiology of MENIERE's disease.
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  • Hisako FUJITA
    1978 Volume 24 Issue 4Supplement2 Pages 630-643
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    The relationship between inner ear function and the course of Meniere's disease was studies in 93 affected ears of 86 patients who had not experienced definitive spells for more than one year as well as for a longer period of time than the longest interval in the past between spells. The following results were obtained.
    1. The course of Meniere's disease was classified into five stages: prior to the initial spell, early, middle, late (equally divided into one third of the duration of the disease) and after the final spell, respectively. There was proved to be no correlation between the progress in hearing loss and the course of these stages. Hearing losses of more than 30 dB were found in 28 of 53 ears (53%) examined after the final spell.
    2. However, in those patients who had suffered for more than three years or had experienced vertiginous spells more than six times, the hearing loss proceeded with the course of the disease.
    3. Regarding semicircular canal function, progressive reduction of caloric response was not observed during the course of this disease, even among the above-mentioned cases.
    4. Semicircular canal function in the stage after the final spell was found to be normal in 17 out of 42 ears (40%) and moderate to complete CP was observed in 22 ears (52%).
    5. Dissociation of cochlear and semicircular canal involvement was found in about one third of the affected ears both in 236 ears of 220 patients and 42 ears of 37 patients examined at their first visits and after the final spells, respectively.
    6. When the patients with Meniere's disease are divided into three groups-vertigo-controlled cases within three years after the initial spell, vertigo-controlled cases over three years and vertigo-uncontrollable cases-these classifications proved, according to multivariable computer analysis, to be closely connected with auditory function, but with no other factors such as number of definitive spell, caloric response, etc.
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  • Naoko KIKUCHI
    1978 Volume 24 Issue 4Supplement2 Pages 644-655
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    I. We conducted questionnaire-research on 65 patients with Meniere's disease who had been treated mainly with drugs for the autonomic nervous system. The observation period after final treatment ranged from two to six years (average 3.8 years). Of the questionnaire papers, 93.8% were returned and the results were as follows.
    1. Varying degrees of improvement of vertigo were noted in 48 out of 61 cases (79%). The medication was confirmed to be effective in 41 cases (67%) within a year.
    2. About one fifth of the patients resisted drug therapy, necessitating other forms of treatments.
    3. Even after the disappearance of the vertiginous attacks, more than half the patients manifested some symptoms, most commonly tinnitus.
    II. Sixty five patients who resisted medication underwent 10-15 regular 20-minute sessions of acupuncture with electric current, and the following results were obtained.
    1. Out of 16 patients with repeated attacks of vertigo, the therapy was effective in eight (50%) whose average hearing loss was less than 30 dB.
    2. Favorable results were obtained in seven out of 18 (39%) and four out of 18 (22%) patients manifesting hearing loss and tinnitus, respectively. Among those for which this therapy was effective, however, there were no patients with severe hearing losses of more than 60 dB.
    3. Two patients who had complained mainly of bodily im balance showed improvement.
    4. Other complaints such as floating sensation, headache, etc., found in 13 patients after the disappearance of vertiginous attacks, were not improved. These results suggest that acupuncture therapy is effective for the early stages of Meniere's disease, in which severe disturbances of inner ear function are not present.
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  • Teruo KOBAYASHI, Reiko KOBAYASHI
    1978 Volume 24 Issue 4Supplement2 Pages 656-659
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    Twenty six cases of low-tone sensorineural deafness of sudden onset were reported. The patients complained of tinnitus, ear fullness and vertigo in 18, two and five cases, respectively. The audiograms showed slight to moderate sensorineural hearing loss in the low tones and positive recruitment. Hearing was recovered in 95% of the cases treated with corticosteroids, vasodilators and vitamins such as thiamine and cobalamin.
    These cases were considered to be a similar entity to endolymphatic hydrops without vertigo as proposed by Williams et al.(1950).
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  • Shigeaki SHIRABE, Toyoji SODA
    1978 Volume 24 Issue 4Supplement2 Pages 660-663
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    Three cases of positional vertigo after total laryngectomy were reported. The period of time from laryngectomy to the onset of vertigo was two weeks, four months and seven months, respectively. The patients were all in their sixties. In the one case whose vertigo appeared seven months after the laryngectomy, a recurrence of the tumor was confirmed in the paratracheal infraclavicular region. This seemed to cause the circulatory insufficiency of the vertebral artery.
    The other two patients manifested positional nystagmus of the benign paroxysmal type. Both patients showed normal hearing acuity and caloric response. We presumed that the paroxysmal positional nystagmus in the two cases was caused by the abnormal state of the cervical sympathetic nerve.
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  • Tamotsu MORIMITSU
    1978 Volume 24 Issue 4Supplement2 Pages 664-669
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    One hundred and four cases of cholesteatoma tretaed by tympanoplasty were classified into two goups: epitympanal type and adhesive otitis type.
    The ossicular chain was destroyed more severely and frequently in the adhesive otitis type, although the mode of invasion into the mastoid was almost same for both. Tympanoplasties of types I, II and III were performed successfully on 61 ro of the epitypanal type and 34% of the adhesive otitis type patients. It was interesting to note that in adhesive otitis type cholesteatoma, the open method produced better results than the closed method. The reason for this was found to lie in the difference between simple otitis media and adhesive otitis media.
    In conclusion, in epitympanal type cholesteatoma, primary tympanoplasty with the closed method was recommended and in the adhesive otitis type, the open method should be considered in some cases.
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  • Shizue AIHARA
    1978 Volume 24 Issue 4Supplement2 Pages 670-673
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    Four cases of recurrent middle ear infection and one case of mastoiditis were reported. Clinical examinations revealed allergy in two, and hypo-gammaglobulinemia, anemia and masked mastoiditis with allergy in each of other three cases, respectively.
    Careful medical attention is required in cases of children because there are, in general, more difficulties both in diagnosis and treatment than with adults.
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  • Naoko KIKUCHI, Hiroko SHOJI
    1978 Volume 24 Issue 4Supplement2 Pages 674-676
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    Topical application of Tobramycin three times daily was effective in eight (89 96) of nine patients with otitis media in whom Pseudomonas or Proteus was detected. Systemic administration of Tobramycin was effective in five (45 96) of 11 patients who underwent surgical treatment for otitis media. No side effects were observed.
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  • Junko SAITO, Yoriko ITOH, Taeko KOIBUCHI, Hajime ARAMAKI
    1978 Volume 24 Issue 4Supplement2 Pages 677-680
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    A case of OSLER'S disease was reported. The patient, a 46-year-old woman, had complained of recurrenct epistaxis for about 20 years. This disease should be considered as one of causes for recurrent epistaxis.
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  • Hiroko SHOJI, Yasuko ARAI, Takuya UEMURA
    1978 Volume 24 Issue 4Supplement2 Pages 681-686
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    A Case of a large posterior ethmoid mucocele easily detected by computerized tomography (CT) was reported. Since this patient had never exprienced nasal difficulties and he had hypertension and diabetes mellitus, the mucocele was found very late and his visual disturbance remained unchanged postoperatively.
    We emphasized the value of CT for the speedy diagnosis of patients who show unilateral blindness and exophthalmus.
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  • Emiko IWASHIMA, Chiga SHIMAZAKI, Junko SAITOH
    1978 Volume 24 Issue 4Supplement2 Pages 687-694
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    During the past three years from 1975 to 1977, tonsillectomies were performed on 638 patients at our clinic. Among these, 42 (6.6%) presented heart disease of congenital origin in 29 cases and of acquired origin in 13 cases. A retrospective study of these patients has shown that tonsillectomy in cases of recurrent tonsillitis should be more intensively indicated in patients with heart disease than in those without complications, because the tonsil in recurrent inflammation can be the site for allergic reaction of type I to IV. Applied immunological progress may expand and modify the indications for tonsillectomy in such cases.
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  • Mikiko TAKAYAMA, Hisako FUJITA, Chiga SHIMAZAKI, Kanae NAKAMURA, Machi ...
    1978 Volume 24 Issue 4Supplement2 Pages 695-699
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    Quantitative analysis of serum amylase isozyme in diseases of the salivary glands was undertaken. The separation of serum amylase in its isozyme was carried out by electrophoresis using cellulose acetate membrane. The fractions stained with blue starch were measured quantitatively by densitometry. The following results were obtained:
    1. An increase of S-type isozyme was found in cases with swelling of the parotid and/or submandibutar glands as well as in cases with sialolithiasis.
    2. In cases of SjOgren's syndrome, the S-type isozyme decreased when the salivary gland function was impaired, but it was within normal limits in patients with xerostomia.
    3. In cases of hyperamylasemia of unknown etiology, increased amylase was necessarily of the S-type. However, the origin of the excessive production was not believed to be the salivary glands.
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  • Yoriko ITOH, Takuya UEMURA, Hisako FUJITA
    1978 Volume 24 Issue 4Supplement2 Pages 700-703
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    A case of acquired laryngeal diaphragma in the subglottic space caused by two intratracheal intubations during heart operations in a child was reported. The lesion was successfully removed by microlaryngosurgery.
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  • Kazumi KAWAI, Junko SUGIYAMA, Reiko KOBAYASHI, Masayoshi KUMAGAI
    1978 Volume 24 Issue 4Supplement2 Pages 704-709
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    Chemotherapy with Bleomycin was carried out very effectively in four patients with recurrent laryngeal papilloma. One hundred and twenty to 1.50mg of Bleomycin was administered intravenously, combined, in some cases, with microlaryngosurgery, to patients who had resisted frequent surgical treatments. No recurrence was seen in follow-up periods ranging from three months to six years after the chemotherapy.
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  • Reiko KOBAYASHI
    1978 Volume 24 Issue 4Supplement2 Pages 710-722
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    In order to clarify the incidence of coexistence of carcinoma in situ and invasive carcinoma of the larynx, the epithelial changes around the invasive laryngeal carcinoma were histologically investigated in 368 cases. The following results were obtained.
    1. Pathological findings in those areas were carcinoma in situ in 141 cases, keratosis with atypia in 68 cases and keratosis without atypia in 57 cases. No pathological changes were noticed in 102 cases.
    2. Carcinoma in situ was found supraglottic in 64 cases, glottic in 62 cases and subglottic in 15 cases. In most, carcinoma in situ was found in the same region or at the site of the invasive carcinoma.
    3. The border of the carcinoma in situ was adjacent to the edges of the invasive carcinoma in 101 cases. In 40 cases, the two lesions were separated by normal epithe lial layers and the distance between the lesions was more than 10mm in 23 of those cases.
    4. Atypical epithelial invasion into the mucous glands was found in 101 cases. These findings showed a high incidence of pathological changes around the invasive carcinoma of the larynx, and suggested it was important in surgical treatment of laryngeal cancer to consider the presence of precancerous and cancerous lesions near the invasive carcinoma.
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  • Hisako KANEKO, Takuya UEMURA, Reiko KOBAYASHI, Hisako FUJITA, Yoshihir ...
    1978 Volume 24 Issue 4Supplement2 Pages 723-727
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    A case of tracheal hamartoma was reported. Since April 1976 the patient, a 34-year-old man, had experienced marked dyspnea after running and sometimes even after talking. One year later, he was diagnosed by roentogenological examination as having a tracheal tumor and he was referred to our hospital. An ordinary chest X-ray film showed a round, smooth tumor shadow occupying the tracheal lumen 3cm above the carina. Tomographic findings also showed a round tumor with slightly lobulated surface without any calcification. The pulmonary function test showed extremely obstructive failure. Under direct bronchoscopy through a tracheostoma, a bright red and smooth-surfaced tumor mass which had a pedicle from the anterior tracheal wall about 5 cm below the tracheostoma was discovered. The tumor having a bleeding tendency was removed. The histopathological diagnosis was hamartoma. Nine months after the surgical removal, no recurrence was seen.
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  • Hajime ARAMAKI, Taeko KOIBUCHI, Hisako FUJITA
    1978 Volume 24 Issue 4Supplement2 Pages 728-731
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    A case of a foreign body, PTP, in the trachea was reported. A 29-year-old man complained of coughing and chest pain two months after mis-swallowing a PTP. Ordinary X-ray examination did not detect the foreign body. Bronchoscopy was carried out under local anesthesia. Two PTP's were lodged in the tracheal wall three cm under the vocal cord. They were removed without complication. The wall of the trachea showed no organic change. The authors warned of the increasing incidence of PTP's becoming lodged not only in the esophagus, but also in the trachea and bronchus.
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  • Kensai SHIRABE
    1978 Volume 24 Issue 4Supplement2 Pages 732-735
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    A case of recurrent foreign bodies in the esophagus of a child was reported. At the time of the first incident, the girl, aged two and a half, had a piece of meat caught in the esophagus. The second time, a year later, it was a piece of sausage. In both cases the foreign bodies were endoscopically removed by forceps. Roentgenological and endoscopical examinations showed no organic change in the esophagus. In both instances, the foreign bodies were located in the same place, where the middle third of the esophagus joins the lower third and where the musculature of the esophagus wall comes to be composed solely of smooth muscles. Thus, it was presumed that in this case the incidents were caused by some functional constriction resulting from peculiarities in the anatomical structure of the organ, actions of the smooth muscles, and innervations, as well as a functional disturbance of the autonomic nervous system. In addition, I made some proposals for preventing foreign body accidents.
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  • Chiga SHIMAZAKI, Hisako FUJITA
    1978 Volume 24 Issue 4Supplement2 Pages 736-740
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    We reported two cases of calcifying epithelioma, a condition rarely seen by otolaryngologists. It is not difficult to diagnose most of calcifying epithelioma by its clinical features. However, as the tumor is sometimes accompanied by blebs or ulcers, the diagnosis should be based on histological findings.
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  • Yasushi NOMURA, Yujiro MATSUMURA, Sanetomi EGUCHI, Tomoko YANAGIDA, Ka ...
    1978 Volume 24 Issue 4Supplement2 Pages 741-750
    Published: 1978
    Released on J-STAGE: May 10, 2013
    JOURNAL FREE ACCESS
    During the past three and a half years (April 1974-September 1977), continuous intra-arterial infusion-radiation therapy was undertaken for 73 cases of cancer of head and neck. Of these, 20 were treated with BUdR continuous intra-arterial infusion. Compared to patients treated with other chemicals, the therapeutic effects in this group were superior: 1) histologically, the tumor cells in the tissue became degenarated and necrotic earlier; 2) clinically, separation of tumors occurred more rapidly; 3) greater difference was noted between the radiosensitivity of the tumor tissue and that of normal tissue, and 4) no side effects attributable to BUdR were observed. Therefore, it was considered to be a safe and effective therapy.
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