Abstract
In order to clarify the incidence of coexistence of carcinoma in situ and invasive carcinoma of the larynx, the epithelial changes around the invasive laryngeal carcinoma were histologically investigated in 368 cases. The following results were obtained.
1. Pathological findings in those areas were carcinoma in situ in 141 cases, keratosis with atypia in 68 cases and keratosis without atypia in 57 cases. No pathological changes were noticed in 102 cases.
2. Carcinoma in situ was found supraglottic in 64 cases, glottic in 62 cases and subglottic in 15 cases. In most, carcinoma in situ was found in the same region or at the site of the invasive carcinoma.
3. The border of the carcinoma in situ was adjacent to the edges of the invasive carcinoma in 101 cases. In 40 cases, the two lesions were separated by normal epithe lial layers and the distance between the lesions was more than 10mm in 23 of those cases.
4. Atypical epithelial invasion into the mucous glands was found in 101 cases. These findings showed a high incidence of pathological changes around the invasive carcinoma of the larynx, and suggested it was important in surgical treatment of laryngeal cancer to consider the presence of precancerous and cancerous lesions near the invasive carcinoma.
