Fundamental Studies on Diffusion of Fosfomycin Sodium of Palatine Tonsil and Mucous Membrane of the Maxillary Sinus

Abstract

We have examined the serum and tissue concentrations of fosfomycin socium (FOM-Na) in patients with chronic tonsillitis and chronic sinusitis. At different times after the drip infusion, samples of serum, palatine tonsil, and mucous membrane of the maxillary sinus were taken, and the concentration of FOM-Na was determined by a microbiological plate diffusion assay using Proteus S. P.(MB 838) as a test bacteria. There was a dose dependent relationship between a 2g and 4g administration of FOM-Na and the serum concentration. The concentration of FOM-Na in palatine tosil was influenced by the degree of adhesion found during the surgery. The concentration in the mucous membrane of the mixillary sinus was influenced by the condition of the mucous membrane. The highest concentration was observed in polypous cases. The diffusion ratio of FOM-Na was higher than other antibiotic, probably due to its lower molecular weight and the absence of serum protein binding.