Abstract
The amount of scattering pollen of gramineae in Osaka and the therapeutic effect of flunisolide nasal solution on pollinosis of gramineae were studied in nine male and seven female patients. In 1984, the pollen of gramineae began to scatter on April 19, peaked in amount during the end of May and the first part of June (max: 37 grains/10 cm3), began to decrease in late June and increased again during mid-August to the first part of September, indicating a biphasic pattern of scattering. Flunisolide nasal solution produced a 73.3 % improvement in sneezing and nasal discharge. The drug produced a symptomatic improvement of “Moderately improved” and “Markedly improved” in 56.3% of the patients and “Slightly improved” or better in 81.3 %. The only adverse reaction reported was one case of nasal irritation. In conclusion, flunisolide nasal solution was demonstrated to be a useful drug for the treatment of pollinosis of gramineae.
