Abstract
Anti-mite IgG antibodies in both serum and nasal secretion were determined in patients with house dust nasal allergy by means of radioallergosorbent test. Polystylen tubes, coated with extracts of Dermatophagoides farinae were used as the solid phase, and 125I-labelled protein A from staphylococcus aureus was used instead of the second antibody. In serum and nasal secretion, mean value of anti-mite IgG antibodies of nasal allergy patients group sensitive to house dust was higher than that of patients group sensitive to other antigens or normal control group. A significant rise of specific IgG antibodies in serum was observed as a result of immunotherapy, but was not observed in nasal secretion. No relationship was obtained between clinical symptoms and the level of IgG antibodies in serum or nasal secretion. These results could not support “blocking antibody” theory.
