Abstract
It was already known that some kinds of ototopical solutions induced sensorineural deafness, if they were used to middle ear infection for long duration. By the above reason, it is the important examination to clarify the influence of new developing otic solution of FOM on the cochlear organ, before clinical use. 32 aminals of Hartley strained guinea pigs were used in this study. All animals received the measurement of Auditory brainstem response (ABR) on stimulation of 20,000Hz and 4,000Hz, using Teledyne Avionics 1000, before they received operation of perforation of ear drums. Left ears were used for evaluation of 1%, 3%, 5% FOM and solvent solution. Right ears were used for the influence of 0.5% chloramphenicol, 2% kanamycin, spontaneous infection and non-treated observation. Ototopical solution dropped in middle ear cavity, continuously for 6 days. After finishing the administration of drugs, animals received ABR, recording and then were sacrificed for pathological examination. As the result, there was no significant difference of ABR recording. The microscopic observation was focused the damage of Corti's organ, especially degeneration of the hair cells. No remarkable changes of Corti's organ were present in 32 left ears in FOM group, in 5 right ears in CP group and in 5 right ears in KM group. FOM otic solution is suggested that it can not affect to the cochlear organ under the above experimental condition.
