Abstract
It has been reported that postoperative bleeding from tonsillar bed after the tonsillectomy based on the hyperfibrinolysis and the insufficiency of fibrin deposit. In this paper, in order to prevent the postoperative bleeding after tonsillectomy the bovine thrombin was administrated on the local sites of tonsillar bed. Furthermore, after the local administration of thrombin, changes of fibrinogen (Fg) content, α2-plasmin inhibitor (α2-PI) activity, antithrombin-III (AT-III) activity, Factor XIII (F XIII) activity and platelet function (ADP and collagen-induced aggregation) were determined, at the same time, macroscopic finding was observed from the aspect of the degree of fibrin deposit in the tonsillar bed. The results obtained from this study were as follows: 1) Fg content, α-PI activity, AT-III activity and F XIII activity were not significantly different between non-administrated group and administrated group of thrombin. 2) ADP and collagen-induced aggregation of platelet were not significantly different before and after the local administration of thrombin. 3) The fibrin deposit (Belag) existed in the tonsillar bed from 5 days to 10 days after the local administration of thrombin. From these-above mentioned results, it was clarified that the local administration of thrombin did not cause DIC on the basis of influx of thrombin into circulating blood. Furthermore, it was suggested that the local administration of thrombin to tonsillar bed is available to prevent the postoperative bleeding after tonsillectomy.
