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Volume 32, Issue 1
Displaying 1-13 of 13 articles from this issue
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Toru SUENAGA, Nobuko DOTA, Fernand Kenji MOGARI, Yoshihiko TERAYAMA1986 Volume 32 Issue 1 Pages 1-4
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSA case of an 8-month-old boy with atypical Mycobacterial otitis media is reported. Initially it was thought to be acute otitis media with effusion, but afterwards was suspected to be Mycobacterium tuberculosis otitis media. Cultures for acid-fast bacilli reveadled a Mycobacterium species. Sections of tissue for Ziel-Nielsen stain also showed acid-fast bacilli. An negative Niacin test established the diagnosis as atypical mycobacterial infection. It was treated with attico-mastoidectomy and isonicotinic acid hydrazine (INAH) administration. There have been only three cases of atypical mycobacterium otitis media so far reported in the English literature, but none in Japanese.View full abstractDownload PDF (2767K) -
Hajime NAKAGAWA, Takatoshi NAGASAKI, Hiroshi INABA, Shinsuke UEDA, Mas ...1986 Volume 32 Issue 1 Pages 5-9
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSRhabdomyosarcoma was found in the nasal cavity and right ethmoid sinus in 27-year-old woman. A final diagnosis was established by several histopathologic examinations including H & E stain, PAS preparation with diastase and immunochemical methods. Z band as a definite evidence of rhabdomyosarcoma was not seen on EM. VAC therapy was performed prior to correct diagnosis and partial remission of the tumor ensured eight weeks after irradiation and Denker's operation with LASER. The patient died of skull base invasion 13 months after the onset of initial symptoms.View full abstractDownload PDF (2851K) -
Takehiko NAGAHAMA1986 Volume 32 Issue 1 Pages 10-13
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSAfter loop diuretic administration, transient hearing loss or tinnitus aurium occurs in some cases, but the clinical features of tinnitus aurium are largely unknown. The audiogram of patients given loop diuretics is usually of the flat type and its grade is middle. In this respect, deafness due to loop diuretics is similar to aspirin induced deafness. The morphological, biochemical and electrophysiological changes caused by both drugs are compared and differences are seen in their pathology. Thus, the genesis of tinnitus aurium remains obscure. Loop diuretics act upon stria vascularis. Its characteristics is useful in the investigation of inner ear deafness or tinnitus.View full abstractDownload PDF (589K) -
Koichi YASUDA1986 Volume 32 Issue 1 Pages 14-16
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSThe labyrinth, visual organs, peripheral organs of deep sensation and their center, the cerebellum, are needed to maintain the equilibrium of the body. Therefore, any disorder that occurs in any part of any such organs gives rise to dysequilibrium with consequent vertigo. Curiously enough, while a vast majority of patients with vertigo have a disorder of the vestibular system, very few exhibit a derangement of the visual organs or of deep sensibility. This communication deals with a patient's experiences with an episode of vertigo of putative deep sensation origin. The patient in this case was a 49-year-old male pharmacist. Since his early childhood he had various deformities of the legs necessitating the use of a cane. His condition was diagnosed by an orthopedic surgeon to be characterized by (1) flexion adduction contracture of the hip joints,(2) compensatory genu valgum and (3) severe pes planovalgus. In 1984 he underwent an adductor tenotomy. When he stood at bedside for the first time after 2 weeks' bed rest following surgery, he had the following unusual feelings:(1) as if the floor on which his feet were touching were sloping left and right and he were standing astride a roof apex;(2) as if he were about to slip down right or leftward;(3) as if his thights and legs were wide open;(4) feeling dizzy soon after standing on his feet and then as if his body were being carried away on a vehicle;(5) his mood was akin to that of motion sickness. These bizarre feelings were progressively reduced as he practiced at standing and walking and were gone in a month. This vertigo is considered to have its origin in an altered deep sensation caused by anatomico-physiological changes that have occurred as a result of the operation. These include medial displacement of the area of contact with the earth in the sole; altered tonicity of the adductors and their antagonists of the thigh; and a change of the position of the knee joint.View full abstractDownload PDF (352K) -
Tadayoshi KOSUGI, Machiko SASAKI, Mariko NAKAMURA, Masaharu URA, Kohei ...1986 Volume 32 Issue 1 Pages 17-25
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSThe physicochemical properties and the pathophysiological significance of human F XIII is well characterized but these properties in rabbit F XIII was not clear until recently. The relationship between the hemostatic system, fibroblast proliferation in wound healing and human F XIII has been investigated in detail. Prior to the study of the change of coagulation-fibrinolysis system after the sinectomy of rabbits, the isolation and partial purification of F XIII from rabbit plasma was done to confirm the existence of F XIII. By means of ammonium sulphate precipitation, PCMB affinity chromatography and Sepharose 6 B gel chromatography, it was determined that F XIII with two different molecular weight, about 140,000 and 400,000 daltons existed in rabbit plasma. The fibrinogen content, α2-plasmin inhibitor and antithrombin III activity were significantly increased after the sinectomy. The change of F XIII activity; however, was not significant. In summary, it was confirmed that F XIII existed in the circulating blood of rabbit as well as human, and it was demonstrated that after the sinectomy of rabbits, F XIII activity did not change significantly in comparison to that before the sinectomy.View full abstractDownload PDF (1066K) -
Akio YOSHIDA, Ryuji NAGANO, Ken OKAMOTO1986 Volume 32 Issue 1 Pages 26-31
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSA retrospective analysis of 103 patients over 70 years old, admitted between July 1979 and December 1984, was performed. Malignant tumor were found in 64 patients, 49 of whom were in their 70's. Laryngeal cancer was most frequent malignancy. Hypertension was most common associated illness. Normal ECG was found in 52.9% of patients in their 70's with malignant tumors, and in 36.4% of patients in their 80's with malignancies. Left ventricular hypertrophy was found most frequently in both generations when the ECG was abnormal. Six cases with malignant tumor of patients in their 70's (10.5%) showed postoperative complications; of these, 3 patients died. Two patients in their 80's with malignant tumors (10%) developed postoperative complication without any sequelae.View full abstractDownload PDF (651K) -
Tatsuhiko MAEHARA, Takeru ISHIKAWA, Norio TANAKA1986 Volume 32 Issue 1 Pages 32-36
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSA case of ethmoidal antrolith was reported. The patient was a 63-year-old male who had worked in the firtilizer industry for 20 years. He visited our clinic on August, 31, 1982, complaining of left nasal obstruction. The caliculus located in the left ethmoid sinus was easily removed by surgery. The caliculus was gray, oval shaped, and weighed 20 grammes (32×26×21mm) without core. This is third largest stone previously reported in Japan. X-ray microanalyser methodology revealed that the main component of caliculus was calcium phosphate and was similar to hydroxy apatite.View full abstractDownload PDF (6890K) -
Katsuichiro OHSAKI, Mamoru KIMURA, Tomoaki SUGIURA, Seikyo SO, Yu MASU ...1986 Volume 32 Issue 1 Pages 37-43
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSIn order to investigate the prolonged factors of otitis media with effusion, we studied the fibrinolytic activity in middle ear fluid. The hydrolytic activities of specific substrates of plasmin and plasminogen activator (P. G. -activator) and the activity of fibrin degradation (fibrinolysis) were measured. Middle ear fluids of 16 cases diagnosed as unilateral otitis media with effusion were tested. Six cases were male and 10 cases were female. Age distribution of the patients were from 31 to 88 years old (mean: 62.4). The middle ear fluid in all cases was either serous or seromucinous. Using specific substrates, determinations of P. G. -activator activity and of plasmin activity were made by the method of CLAESON et al and the fibrinolysis was determined by the standard fibrin plate method. The results were as follows: 1) Both activities for decomposition of amide against the specific substrates of plasmin and of P. G. -activator were revealed. 2) Fibrinolysis was divided into two categories: fibrinolysis (-) group in six cases (37.5%) and fibrinolysis (+) group in eight cases (50.0%). The characteristics and the roles of fibrinolytic enzymes in the middle ear fluid of otitis media with effusion is discussed.View full abstractDownload PDF (865K) -
Inter-group Comparative Study with Betahistine Mesylate by Multi-centered Double-blind TrialMasaaki KITAHARA, Isamu WATANABE, Manabi HINOKI, Kanemasa MIZUKOSHI, T ...1986 Volume 32 Issue 1 Pages 44-92
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSClinical effect of Isosorbide (ISO) was studied in patients with Meniere's disease from their subjective symptoms and objective findings by multi-centered double-blind trial with Betahistine Mesylate (BM) as a reference drug. 1) Global improvement rating: ISO-treated group was more superior than BM-treated group in 2 weeks and 4 weeks after administration with a statistically significant difference (P<0.05) in Wilcoxon test when statistical analysis was made based on the judgement by investigators, however, there was no statistically significant difference between both groups when analyzed based on the judgement by the Committee. 2) Utility rate: Upon the judgement by investigators, ISO-treated group was more superior than BM-treated group in 2 weeks and 4 weeks after administration with a tendency of statistical difference in Wilcoxon test, however, there was no statistically significant difference between both groups upon the judgement by the Committee. 3) Side effect, clinical laboratory test and safety rate: There was no particular difference between both groups. From the above results, it was concluded that ISO was an effective and useful drug for Meniere's disease.View full abstractDownload PDF (4765K) -
Shunkichi BABA, Haruji KINOSHITA, Yoshito MORI, Kenji SUZUKI, Ichiro F ...1986 Volume 32 Issue 1 Pages 93-111
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSAntibacterial test and clinical studies were performed in order to evaluate efficacy and safety of Aztreonam in the treatment of acute sinusitis, acute exacerbation of chronic sinusitis and chronic sinusitis and the following results were obtained. 1. MIC showed its peak at≤0.025μg/ml for the 17 G-negative strains isolated from the patients with sinusitis. There were 9 H. influenzae strains among them and all the strains distributed below MIC 0.1μg/ml. 2. Clinical effective rate of Aztreonam for 5 acute sinusitis cases, 10 acute exacerbated cases of chronic sinusitis and 19 chronic sinusitis cases were 100%, 70.0% and 31.6% respectively. Overall effective rate of the above 34 cases was 52.9%. 3. Biological effect of Aztreonam by pathogen was reviewed to find that all the 21 G-negative pathogens had been eradicated. For the 18 G-positive pathogens, eradication rate was naturally only 33.3%. 4. None of the side effects was reported. However, one case of GOT elevation and one case of GOT·GPT·Al-P elevations were noted as laboratory abnormalities although all of them were minor and trasient. It was considered from the above results that Aztreonam is a highly useful drug in sinusitis.View full abstractDownload PDF (3968K) -
Shozo KAWAMURA, Norio UEHARA, Eiichi KATO, Yutaka FUJIMAKI, Hiroshi WA ...1986 Volume 32 Issue 1 Pages 113-144
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSTo know an adequate concentration of FOM in an otic solution, 0.5, 1 or 3% otic solution was administered to patients with suppurative otitis media in the manner of well controlled study and the results were as follows: 1) The effectiveness rate judged by physician incharge was the highest for the 3% group, 67.9%, but no significant difference was observed. 2) The effectiveness rate judged by the Committee was the highest for the 3% group, 62.3%, but no significant difference was observed. 3) As to improvement rate of subjective and objective findings, significantly higher rate was obtained with 3% group in ear obstruction, perforation, and properties of discharge from middle ear. 4) Bacteriological elimination rate of causative organisms in all cases were the highest for the 3% group, but no significant difference was observed. 5) Some side effects and adverse reaction were observed in 4 patients in the 3% group, i. e., one case each of irritative feeling, uncomfortable feeling, otitis externa and heavy feeling in the ear. No serious symptom was observed. 6) The usefulness rate judged by physician incharge was the highest for the 3% group, 69.1%, but no significant difference was observed. From these results, it was concluded that the 3% otic solution is superior to the 0.5 and 1%, having very high usefulness, as new otic preparation for the treatment of suppurative otitis media infection.View full abstractDownload PDF (3078K) -
Shizuo KOJA, Hidenori TOMORI, Satoru YOSHIDA, Yutaka NODA, Mariko NAKA ...1986 Volume 32 Issue 1 Pages 145-154
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSIt has been reported that postoperative bleeding from tonsillar bed after the tonsillectomy based on the hyperfibrinolysis and the insufficiency of fibrin deposit. In this paper, in order to prevent the postoperative bleeding after tonsillectomy the bovine thrombin was administrated on the local sites of tonsillar bed. Furthermore, after the local administration of thrombin, changes of fibrinogen (Fg) content, α2-plasmin inhibitor (α2-PI) activity, antithrombin-III (AT-III) activity, Factor XIII (F XIII) activity and platelet function (ADP and collagen-induced aggregation) were determined, at the same time, macroscopic finding was observed from the aspect of the degree of fibrin deposit in the tonsillar bed. The results obtained from this study were as follows: 1) Fg content, α-PI activity, AT-III activity and F XIII activity were not significantly different between non-administrated group and administrated group of thrombin. 2) ADP and collagen-induced aggregation of platelet were not significantly different before and after the local administration of thrombin. 3) The fibrin deposit (Belag) existed in the tonsillar bed from 5 days to 10 days after the local administration of thrombin. From these-above mentioned results, it was clarified that the local administration of thrombin did not cause DIC on the basis of influx of thrombin into circulating blood. Furthermore, it was suggested that the local administration of thrombin to tonsillar bed is available to prevent the postoperative bleeding after tonsillectomy.View full abstractDownload PDF (6704K) -
Nobuharu TAGASHIRA, Koji YAJIN, Koji SERA, Yasuo HARADA, Shunbun TAKEB ...1986 Volume 32 Issue 1 Pages 155-163
Published: January 20, 1986
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSClinical evaluation of ototopical solution with 3% FOM were performed for 21 patients of chronic suppurative otitis media (5 cases) and its acute exacerbation (16 cases). The results were obtained as follows. 1) The overall clinical effect was excellent in 9 cases, good in 6, fair in 5, poor in 1, clinical effectiveness rate was 71.4%. 2) Especially, a satisfactory clinical response was obtained in mixed infection. 3) No side effects were observed in any case.View full abstractDownload PDF (952K)
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