Abstract
Antibacterial test and clinical studies were performed in order to evaluate efficacy and safety of Aztreonam in the treatment of acute sinusitis, acute exacerbation of chronic sinusitis and chronic sinusitis and the following results were obtained. 1. MIC showed its peak at≤0.025μg/ml for the 17 G-negative strains isolated from the patients with sinusitis. There were 9 H. influenzae strains among them and all the strains distributed below MIC 0.1μg/ml. 2. Clinical effective rate of Aztreonam for 5 acute sinusitis cases, 10 acute exacerbated cases of chronic sinusitis and 19 chronic sinusitis cases were 100%, 70.0% and 31.6% respectively. Overall effective rate of the above 34 cases was 52.9%. 3. Biological effect of Aztreonam by pathogen was reviewed to find that all the 21 G-negative pathogens had been eradicated. For the 18 G-positive pathogens, eradication rate was naturally only 33.3%. 4. None of the side effects was reported. However, one case of GOT elevation and one case of GOT·GPT·Al-P elevations were noted as laboratory abnormalities although all of them were minor and trasient. It was considered from the above results that Aztreonam is a highly useful drug in sinusitis.
