Cefoperazone Levels in Otorrhea and Clinical Efficacy

Abstract

The transfer of Cefoperazone (CPZ) into otorrhea, and the clinical effectiveness of CPZ as a therapeutic agent were studied. 1. The levels of CPZ in otorrhea follwing intravenous injection of 2g CPZ were determined by bioassay using E. coli NIHJ as a test organism. The peak CPZ level in otorrhea was seen about 60 minutes after injection in patients who secreted relatively small amount of otorrhea, while that of in patients who secreted moderate to large amount of otorrhea was tended to be observed earlier than 60 minutes. 2. A total of 21 patients suffering from chronic otitis media (12), cholesteatoma (2) and acute otitis media (1) or recieving radical mastoidectomy (3) were treated with 1 to 4g/day CPZ during pre- and/or post-operative period. Of these 21, 17 (81.0%) had a satisfactory clinical response following CPZ therapy. 3. Clinical effectiveness in terms of major causative organisms, of 7 cases in whom P. aeruginosa was isolated, and of 4 cases in whom S. aureus was isolated, 5 (71.4%) and 3 (75.0%), respectively were effectively treated with CPZ. 4. No statistically significant correlation was observed between the levels of CPZ in otorrhea and clinical effectiveness.