A case of radiation-induced cancer at the base of the tongue showing complete response to combination chemotherapy (VMPM and VPCP regimens)

Abstract

This report concerns a 47-year-old woman suffering from radiation-induced cancer at the base of the tongue. She received radiation for the treatment of tuberculosis the cervical lymph nodes prior to the diagnosis of the radiation induced cancer. This patient was treated with noncrossresistant combination chemothrapy including VMPM (a combination of VCR, MTX, PEP and MMC) and VPCP (a combination of VCR, PEP, CDDP and PEP) regimens. She showed complete response (CR) to the treatment. Interstitial pneumonia occurred as a side effect of MTX during the course of this treatment. No recurrence has been found under mirror-laryngoscopy and the complete response has been maintained for 3 years after the treatment.