Abstract
The muco-regulator, carbocysteine (S-CMC, Mucodyne), is clinically used for the treatment of upper respiratory infection, although the pharmacokinetics in our field are not so clear. In this study, the authors evaluated the influence of S-CMC on experimentally induced rhino-sinusitis. Rhino-sinusitis was induced in Hartley strain guinea pigs by exposing them to formaldehyde gas. Ten animals were divided into two groups of five. The first group was orally administered S-CMC at a dose of 200mg/kg for 6 days. The second group (control) was observed without S-CMC. The animals were sacrificed on the seventh day under general anesthesia and the nasal tissues, including the sinuses were examined through histological and SEM methods. Results were as follows: Serous nasal discharge was increased in both groups: however, the control group showed more mucoid fluids remaining compared with the experimental group. The control group also showed more severe inflammation when compared to the control group. It is thought that S-CMC acts on the goblet cells of the nasal mucous membrane and increases the flow of nasal discharge.
