Abstract
NAC has been performed in 13 cases of non-treated squamous cell carcinoma of the hypopharynx. According to our NAC regimen, the cases were divided into 2 groups: the VPCP group (n=7), in which VCR, CDDP and PEP were used; and the ACP group (n=6), in which ADR or THP-ADR, CDDP and PEP were used. Therapeutic effects of NAC in 13 cases were found as CR in 1 case, PR in 8 cases, NC in 3 cases and PD in 1 case, with an effectiveness rate of 69%. Cumulative survival rates using the Kaplan-Meier method in 13 cases were 75% at 12 months and 62% at 52 months. These results suggest that NAC may be incorporated into a therapeutic method for treating hypopharyngeal carcinoma. Further investigation of this method in essential to improve its long term results.
