Combined effects of Norfloxacin and Carbocistein for suppurative otitis media

Abstract

The combined effects of Norfloxacin(NDLX)and Carbocistein(SCMC)for suppurative otitis media were examined. The patients were divided into two groups and treated for seven days. The 37 patients in the first group were prescribed NFLX 600mg/day alone. The other group (24 patients) received NFLX 600mg/day and SCMC 1500mg/day in combination. the following results were obtained; 1. The overall clinical excellent effiacy rate was 40.5% in the NFLX alone group and 45.8% in the combined group. The moderate efficacy rates were 67.6%and 75.0% in the two groups, respectively. 2. Aural discharge completely resolved in 55.6% of the NFLX alone caces adn in 69.6% if the combined cases. Moderate improvement was noted in the two guoups in 77.8% and 82.6% of the patients, respectively. The volume of aural discharge was decreased dramatically in 55.6% and 69.6% of patients in the two groups, respectively. Volume was decreased moderately in 88.9% and 97.5% of patients in the two groups, respectively. Therefore, the efficacy rate of the NFLX and SCMC combined group wass superior to that of the NFLX alone group. However, the differences between the two groups were not statistically significant. The combined effcet was observed especially in the acute otitis media cases, 3. It was concluded that these data showed the combined effcet of NFLX and SCMC in the treatment of suppurative otitis media.