jibi to rinsho
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
Clinical Studies of Fluticasone Propionate Aqueous Nasal Spray (3rd Report)
A Study in Vasomotor Rhinitis
Minoru OKUDA, Tokuji UNNO, Yoshihisa SASAKI, Hiroshi TOMITA, Shunkichi BABA, Toru MATSUNAGA, Yukio INUYAMA, Satoshi FUKUDA, Akikatsu KATAURA, Koji ASAKURA, Tadashi KOJIMA, Mitsuaki TAKAHASHI, Naoki HATAYAMA, Akira NAKAMURA, Osamu YANAI, Nobuo SAKAMOTO, Jiro HOZAWA, Atsushi MATSUBARA, Tomonori TAKASAKA, Naoki INAMURA, Jun-ichi SATAKE, Kotaro BABA, Hitoshi SHIMADA, Jiro MUTO, Shigeru OMACHI, Toshio ISHIZAKA, Akira SAITO, Tetsuzo INOUE, Manabu NAKANOBO, Yasuo TANAKA, Hitoshi KIYONO, Shun-ichi TOMIYAMA, Akinori MEZAWA, Akiyoshi KONNO, Yosuke FUJITA, Takayuki YAMAKOSHI, Masaki ONISHI, Masakazu IKEDA, Hideaki KOYAMA, Kumiko YAMADA, Kaoru SATO, Kyozo KIKUCHI, Kiyoshi MAKIYAMA, Kenji OKAZAKI, Yasuya NOMURA, Masahiro MIZUNO, Harumi SUZAKI, Yozo SAITO, Tetsuo ISHII, Midori NABESHIMA, Ichiyo KUBOTA, Yoshio HONDA, Tomohiko ENDO, Nobuo USUI, Koichi ITO, Hiroshi OGAWA, Kazuhiro HASHIGUCHI, Tetsuya SHITARA, Hirosato MIYAKE, Atsushi SHINKAWA, Hideshige KIMURA, Yasuo HATTORI, Masako KAJIMOTO, Isamu TAKEYAMA, Keisuke UESUGI, Hiroyuki ZUSHO, Shuju SAWAKI, Seiichiro YUYAMA, Yuichi NAKANO, Masuo YAMAGISHI, Hitoshi SAITO, Shigeharu FUJIEDA, Shigehito MORI, Hiroshi YAJIMA, Yasuyuki NAGASHIMA, Atsushi USAMI, Noriyuki YANAGITA, Tsutomu NAKASIMA, Toru SUZUKI, Joh NISHIMURA, Akira YOKOTA, Hiromi ITO, Yasuhiko OYA, Haruo ITO, Jun-ichiro SHIMADA, Shigenobu IWATA, Akihiko TAKASU, Nobuo TAKEDA, Yasuo SAKAKURA, Kotaro UKAI, Sawako MASUDA, Yasushi MURAKAMI, Hiroshi TAKENAKA, Kenji SAITO, Satoshi KUMAZAWA, Tadami KUMAZAWA, Nobuo KAWAMURA, Shigeki OGINO, Yoshikiyo SAKAGUCHI, Keizo MORIMATSU, Jun-ichi YOSHIDA, Michihiro NOSE, Osamu SENBA, Yoshiaki NAKAI, Yoshihiro OHASHI, Hirokazu SAKAMOTO, Toshihide TABATA, Jun-ichi YODA, Mutsuo AMATSU, Haruhiko ISHIDA, Hirofumi MIYAKE, Yasuo HARADA, Katsuhiro HIRAKAWA, Kazuhiko KUSAKA, Hisaaki IKOMA, Takeo SUZUKI, Goro MOGI, Hideyuki KAWAUCHI, Atsuo CHAEN, Takeru ISHIKAWA, Keisuke MASUYAMA, Yasuaki SADANAGA, Masaru OYAMA, Yasuhiro MIYAZAKI, Masahiko EGAWA
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Keywords: Fluticasone propionate
JOURNAL FREE ACCESS

1993 Volume 39 Issue 1 Pages 49-65

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Abstract
To evaluate its clinical efficacy and safety, Fluticasone Propionate Aqueous Nasal Spray (FP ANS) was administered to 79 patients with vasomotor rhinitis in the dose of 200mcg/day for at least 2 weeks in principle (One received for 21 weeks). The following results were obtained. 1. In the assessment of final overall improvement, cases judged as “markedly improved” or “moderately improved” accounted for 72.7%, and the cumulative rate including “slightly improved” cases was 92.7%. 2. An adverse reaction, mild palpitation, occurred in 1 case. No abnormality was observed in the clinical laboratory test values. Based on the above results, FP ANS was confirmed to be an effective and safe drug for the treatment of vasomotor rhinitis.
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