Fluticasone propionate点鼻液の臨床的検討 (第5報) 通年性鼻アレルギーに対するFluticasone propionateエアゾール剤との比較試験

奥田 稔; 冨田 寛; 馬場 駿吉; 大西 正樹; 池田 雅一; 小山 英明; 山田 久美子; 佐藤 かおる; 目澤 朗憲; 菊池 恭三; 牧山 清; 岡崎 健二; 野村 恭也; 水野 正浩; 洲崎 春海; 川村 理恵; 斎藤 洋三; 石井 哲夫; 鍋島 みどり; 窪田 市世; 荒牧 元; 新井 寧子; 宮野 良隆; 横内 載子; 本多 芳男; 遠藤 朝彦; 山口 宏也; 河合 敏; 舩坂 宗太郎; 佐伯 哲郎; 河野 淳; 和田 昌士; 鈴木 栄一; 臼井 信郎; 金沢 博俊; 小田 恂; 長舩 宏隆; 原田 克也; 小倉 麻美子; 岩村 忍; 栗田 宣彦; 畑 裕子; 神崎 仁; 坂井 真; 佐藤 むつみ; 加賀 達美; 鈴木 淳一; 加我 君孝; 都筑 俊寛; 大西 信治郎; 小川 浩司; 橋口 一弘; 斎藤 等; 藤枝 重治; 森 繁人; 柳田 則之; 中島 務; 鈴木 亨; 小出 純一; 西村 穣; 横田 明; 伊藤 弘美; 大屋 靖彦; 伊藤 晴夫; 島田 純一郎; 岩田 重信; 高須 昭彦; 武田 伸郎; 坂倉 康夫; 鵜飼 幸太郎; 増田 佐和子; 村上 泰; 竹中 洋; 斎藤 憲治; 小川 暢也

doi:10.11334/jibi1954.39.1_86

Clinical studies of Fluticasone Propionate Aqueous Nasal Spray (5th report)

Comparative study vs. Fluticasone Propionate Aerosol

Minoru OKUDA, Hiroshi TOMITA, Shunkichi BABA, Masaki ONISHI, Masakazu IKEDA, Hideaki KOYAMA, Kumiko YAMADA, Kaoru SATO, Akinori MEZAWA, Kyozo KIKUCHI, Kiyoshi MAKIYAMA, Kenji OKAZAKI, Yasuya NOMURA, Masahiro MIZUNO, Harumi SUZAKI, Rie KAWAMURA, YOZO SAITO, Tetsuo ISHII, Midori NABESHIMA, Ichiyo KUBOTA, Hajime ARAMAKI, Yasuko ARAI, Yoshitaka MIYANO, Noriko YOKOUCHI, Yoshio HONDA, Tomohiko ENDO, Hiroya YAMAGUCHI, Satoshi KAWAI, Sotaro FUNASAKA, Tetsuro SAEKI, Atsushi KAWANO, Masashi WADA, Eiichi SUZUKI, Nobuo USUI, Hirotoshi KANAZAWA, Makoto ODA, Hirotaka OSAFUNE, Tatsuya HARADA, Mamiko OGURA, Shinobu IWAMURA, Nobuhiko KURITA, Yuko HATA, Jin KANZAKI, Makoto SAKAI, Mutsumi SATO, Tatsumi KAGA, Jun-ichi SUZUKI, Kimitaka KAGA, Toshihiro TSUZUKU, Shinjiro ONISHI, Hiroshi OGAWA, Kazuhiro HASHIGUCHI, Hitoshi SAITO, Shigeharu FUJIEDA, Shigehito MORI, Noriyuki YANAGITA, TSUTOMU NAKASHIMA, Toru SUZUKI, Jun-ichi KOIDE, Joh NISHIMURA, Akira YOKOTA, Hiromi ITO, Yasuhiko OYA, Haruo ITO, Jun-ichiro SHIMADA, Shigenobu IWATA, Akihiko TAKASU, Nobuo TAKEDA, Yasuo SAKAKURA, Kotaro UKAI, Sawako MASUDA, Yasushi MURAKAMI, Hiroshi TAKENAKA, Kenji SAITO, Nobuya OGAWA

Author information

Minoru OKUDA
Department of Otorhinolaryngology, Nippon Medical School
Hiroshi TOMITA
Department of Otorhinolaryngology, Nihon University, School of Medicine, Itabashi Hospital
Shunkichi BABA
Department of Otorhinolaryngology, Nagoya City University Nedical School
Masaki ONISHI
Department of Otorhinolaryngology, Nippon Medical School
Masakazu IKEDA
Department of Otorhinolaryngology, Nippon Medical School
Hideaki KOYAMA
Department of Otorhinolaryngology, Nihon University, School of Medicine, Itabashi Hospital
Kumiko YAMADA
Department of Otorhinolaryngology, Nihon University, School of Medicine, Itabashi Hospital
Kaoru SATO
Department of Otorhinolaryngology, Nihon University, School of Medicine, Itabashi Hospital
Akinori MEZAWA
Department of Otorhinolaryngology, Hakujikai Memorial Hospital
Kyozo KIKUCHI
Department of Otorhinolaryngology, Surugadai Hospita1, Nihon University School of Medicine
Kiyoshi MAKIYAMA
Department of Otorhinolaryngology, Surugadai Hospita1, Nihon University School of Medicine
Kenji OKAZAKI
Department of Otorhinolaryngology, Surugadai Hospita1, Nihon University School of Medicine
Yasuya NOMURA
Department of Otorhlnolaryngology, Faculty of Medicine, Unlversity Qf Tokyo
Masahiro MIZUNO
Department of Otorhlnolaryngology, Faculty of Medicine, Unlversity Qf Tokyo
Harumi SUZAKI
Department of Otorhlnolaryngology, Faculty of Medicine, Unlversity Qf Tokyo
Rie KAWAMURA
Department of Otorhlnolaryngology, Faculty of Medicine, Unlversity Qf Tokyo
YOZO SAITO
Department of Otorhlnolaryngology, Tokyo Medical and University, School of Medicine
Tetsuo ISHII
Department of Otorhinolaryngology, Tokyo Women's Medical College
Midori NABESHIMA
Department of Otorhinolaryngology, Tokyo Women's Medical College
Ichiyo KUBOTA
Department of Otorhinolaryngology, Tokyo Women's Medical College
Hajime ARAMAKI
Department of Otorhinolaryngology, Tokyo Women's Medical College Dai-ni Hospital
Yasuko ARAI
Department of Otorhinolaryngology, Tokyo Women's Medical College Dai-ni Hospital
Yoshitaka MIYANO
Department of Otorhinolaryngology, Tokyo Women's Medical College Dai-ni Hospital
Noriko YOKOUCHI
Department of Otorhinolaryngology, Tokyo Women's Medical College Dai-ni Hospital
Yoshio HONDA
Department of Otorhinolaryngology, The Jikei University School of Medicine
Tomohiko ENDO
Department of Otorhinolaryngology, The Jikei University School of Medicine
Hiroya YAMAGUCHI
Department of Otorhinolaryngology, Tokyo Senbai Hospital
Satoshi KAWAI
Department of Otorhinolaryngology, Tokyo Senbai Hospital
Sotaro FUNASAKA
Department of Otorhinolaryngology, Tokyo Medical College
Tetsuro SAEKI
Department of Otorhinolaryngology, Tokyo Medical College
Atsushi KAWANO
Department of Otorhinolaryngology, Tokyo Medical College
Masashi WADA
Department of Otorhinolaryngology, Tokyo Rosai Hospital
Eiichi SUZUKI
Department of Otorhinolaryngology, Dai-ichi Hospital, Nippon Medical School
Nobuo USUI
Department of Otorhinolaryngology II, Toho University School of Medicine
Hirotoshi KANAZAWA
Department of Otorhinolaryngology II, Toho University School of Medicine
Makoto ODA
Department of Otorhinolaryngology, Toho University, School of Medicine
Hirotaka OSAFUNE
Department of Otorhinolaryngology, Toho University, School of Medicine
Tatsuya HARADA
Department of Otorhinolaryngology, Toho University, School of Medicine
Mamiko OGURA
Department of Otorhinolaryngology, Toho University, School of Medicine
Shinobu IWAMURA
Department of Otorhinolaryngology, Mitsui Memorial Hospital
Nobuhiko KURITA
Department of Otorhinolaryngology, Mitsui Memorial Hospital
Yuko HATA
Department of Otorhinolaryngology, Mitsui Memorial Hospital
Jin KANZAKI
Department of Otorhinolaryngology, Keio University School of Medicine
Makoto SAKAI
Department of Otorhinolaryngology, Tokyo Hospital, School of Medicine, Tokai University
Mutsumi SATO
Department of Otorhinolaryngology, Tokyo Hospital, School of Medicine, Tokai University
Tatsumi KAGA
Department of Otorhinolaryngology, Tokyo Hospital, School of Medicine, Tokai University
Jun-ichi SUZUKI
Department of Otorhinolaryngology, Teikyo University School of Medicine
Kimitaka KAGA
Department of Otorhinolaryngology, Teikyo University School of Medicine
Toshihiro TSUZUKU
Department of Otorhinolaryngology, Teikyo University School of Medicine
Shinjiro ONISHI
Department of Otorhinolaryngology, Kanto Teishin Hospital
Hiroshi OGAWA
Department of Otorhinolaryngology, Kitasato Institute Hospital
Kazuhiro HASHIGUCHI
Department of Otorhinolaryngology, Kitasato Institute Hospital
Hitoshi SAITO
Department of Otorhinolaryngology, Fukui Medical School
Shigeharu FUJIEDA
Department of Otorhinolaryngology, Fukui Medical School
Shigehito MORI
Department of Otorhinolaryngology, Fukui Medical School
Noriyuki YANAGITA
Department of Otorhinolaryngology, Nagoya University School of Medicine
TSUTOMU NAKASHIMA
Department of Otorhinolaryngology, Nagoya University School of Medicine
Toru SUZUKI
Department of Otorhinolaryngology, Nagoya University School of Medicine
Jun-ichi KOIDE
Department of Otorhinolaryngology, Chukyo Hospital
Joh NISHIMURA
Department of Otorhinolaryngology, Nagoya City University Nedical School
Akira YOKOTA
Department of Otorhinolaryngology, Nagoya City, Higashi General Hospital
Hiromi ITO
Department of Otorhinolaryngology, Nagoya City, Higashi General Hospital
Yasuhiko OYA
Department of Otorhinolaryngology, Nagoya City, Midori General Hospital
Haruo ITO
Department of Otorhinolaryngology, Koseiren Showa Hospital
Jun-ichiro SHIMADA
Department of Otorhinolaryngology, Koseiren Kamo Hospital
Shigenobu IWATA
Department of Otorhinolaryngology, Fujita Health Unlversity School of Medic{ne
Akihiko TAKASU
Department of Otorhinolaryngology, Fujita Health Unlversity School of Medic{ne
Nobuo TAKEDA
Department of Otorhinolaryngology, Fujita Health Unlversity School of Medic{ne
Yasuo SAKAKURA
Department of Otorhinolaryngology, School of Medicine, Mie University
Kotaro UKAI
Department of Otorhinolaryngology, School of Medicine, Mie University
Sawako MASUDA
Department of Otorhinolaryngology, School of Medicine, Mie University
Yasushi MURAKAMI
Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine
Hiroshi TAKENAKA
Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine
Kenji SAITO
Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine
Nobuya OGAWA
Department of Pharmacology, Ehime University School of Medicine

Keywords: Fluticasone propionate

JOURNAL FREE ACCESS

1993 Volume 39 Issue 1 Pages 86-106

DOI https://doi.org/10.11334/jibi1954.39.1_86

Details

Abstract

In patients with perennial allergic rhinitis, clinical efficacy and safety of Fluticasone Propionate (FP) Aqueous Nasal Spray (ANS) and FP Aerosol were compared in a single blind study. 176 cases receiving 200mcg/day in two divided doses for 2 weeks were included in the analysis, and both drugs produced high improvement rates (total of the cases assessed as “markedly improved” and those as “moderately improved” : ANS 81% and Aerosol 70%). A low incidence of adverse reactions and abnormal clinical laboratory test values resulted in a high safety rating in the overall safety assessment (“high level of safety” : ANS 99% and Aerosol 100%). Clinical usefulness was assessed based on the efficacy and safety results, and both the drugs were judged as very useful (total of “very useful” and “useful” : ANS 81% and Aerosol 73%). Thus, both FP ANS and Aerosol were found to be useful drugs for perennial allergic rhinitis.

Corresponding author

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