Inhibitory effect of Neurotropin on increased methacholine hyperresponsibility of the nasal mucosa in guinea pigs treated intranasally with OS-oil

Abstract

In the present study, the mode of action of Neurotropin on nasal allergic reaction was compared with that of ketotifen using guinea pigs (OS-animals), which resulted in non-specific hyperresponsibility by repeated nasal challenges with OS-oil. Daily administration of Neurotropin at doses of 10 to 50mg/kg i. p. for 8 consecutive days normalized the methacholine responsibility as well as the nasal response to the allergen in the passively sensitized OS-animals. Ketotifen at a does of 1mg/kg p. o. also inhibited nasal secretion markedly in the passively sensitized OS-guinea pigs, but decreased slightly the nasal methacholine hyperresponsibility. Thus, the effect of Neurotropin on nasal symptoms. i. e. watery secretion and sneezing, may be due to its inhibitory action on nasal hyperresponsibility.