Abstract
We administered three tablets of Metharmon-F, which contains 1.0mg of pregnenolone, 0.1mg of testosterone, 1.0mg of androstenedione, 5μg of estrone, 0.5mg of androstenediol and 7.5mg of desiccated thyroid per tablet, daily for 2-4 weeks to 37 middle-aged female patients with an abnormal sensation in the throat who had been resistant to prior therapy with lysozyme chloride for 2 weeks or more. At the end of administration, the efficacy of the drug with regard to the throat discomfort was marked in 27% of the patients, moderate in 30% and slight in 16%. The drug was also effective against various accompanying symptoms such as fatigue, headache or stiff shoulders with a certain degree of correlation to its effective ness for the throat symptom. A mild side effect (dry throat) was reported by one patient (3%), but it disappeared during the period of drug administration. Metharmon-F was found to compensate for the ineffectiveness of lysozyme chloride in the therapy of female patients with throat discomfort. Therefore, the combined use of the two drugs may produce satisfactory results in the therapy of such patients.
