Abstract
In 1965 Soeda and Sambe extracted an antigenic substance from the urine of allergic patients and we named this substance MS-Antigen (MS-A). This agent has an antigenic character and has no allergy provoking property. The most striking finding is that both anaphylactic shock and Arthus reaction are suppressed by this substance. In a clinical study of MS-A, a 34-year-old woman was treated with this agent. She had been suffering from uticaria with beer or yellowtails as well as recurrent aphthous stomatitis for six years. Urticaria and recurrent aphtae subsided and disappeared simultaneously after the 25times injection of 40mg of this agent. We confirmed that MS-A was effective in treating recurrent aphthous stomatitis. Recurrent stomatitis is related to various factors. It was postulated from the results of the above allergy tests (family anamese, complications of allergic diseases, skintest, etc.) that recurrent aphthous stomatitis, including Behcet's disease, might be allergic and thus the treatment with this agent was carried out. Behcet's disease is a very difficult disesase to treat and the chief symptoms are aphthous stomatitis, uveitis and pudental ulcer. We have now treated 4 cases of Bebcets's disease with this agent and obtained good clinical results: Up to now two cases were excellent, one case was good and one case was poor. Clinical results of 46 cases of recurrent aphthae: Excellent responses were achieved in 16 cases and satisfactory responses were achieved in 19 cases. In addition, no adverse side-effects have been observed.
