Abstract
The effects of the combined use of drugs on smell disturbance due to chronic sinusitis were studied in 15 patients. Roxithromycin (RXM) was orally administered as the main drug at a dosage of 300mg in two divided doses, while Azelastine hydrochloride (AH) was orally administered as the concomitant drug in a daily dosage of 2 mg in two divided doses. The administration period was eight weeks. In the group administered RXM alone (7 patients), smell disturbance was observed to improve in 71% of the cases, while it improved in 67% in the group given both RXM and AH (8 patients); the difference was not statistically significant. In one case from the RXM+AH administration group, however, the efficacy was excellent, which indicated a potential advantage of the combined drug use. It is still necessary to more carefully evaluate this approach employing both a lager number of patients as well as developing a more objective method for its assessment.
