Abstract
In 1965 Soeda and Sambe extracted an antigenic substance (peptides) from the urine of allergic patients and named it MS-Antigen (R)(MS-A). This agent has an antigenic character and has no allergy provoking property. The most striking finding is that both anaphylactic shock and Arthus reaction are suppressed by this agent. Ten subjects, whose allergens had already been identified through skin testing to be derived from Japanese cedar pollen, etc., were randomly selected from the outpatients who had been regularly administered MS-A (40mg) twice a week. The marked clinical effectiveness of MS-A was thus proven without any local or systemic side-effects. Subsequently, we have since been extending our investigation to the therapeutic effects of MS-A on such allergic diseases as pollinosis as well as other diseases that are all more or less related to allergies, from both a clinical and immunological point of view. This study discusses the clinical aspect of MS-A regarding such allergic diseases as pollinosis, as well as other diseases including Behcet's disease and Pustulosis palmo-plantaris.
