Abstract
Background) The pre-seasonal medication for patients with Japanese cedar pollinosis is now widely accepted and well known to delay the onset of symptoms, while also decreasing the severity of symptoms during the peak cedar pollen season. Oral selective H1-antagonist is frequently used as a one such pre-seasonal drug. In this study, levocabastine nasal spray, a selective H1-antagonist was administered to patients with Japanese cedar pollinosis as a pre-seasonal drug. Methods) Sixteen patients (6male; 10 female, mean: 42.8 year-old) were enrolled and divided into 2 groups, consisting of a pre-seasonal medication group and an in-seasonal medication group. Pre-seasonal medication using levocabastine nasal spray was started 2 weeks before the beginning of pollen season. Another group also used levocabastine nasal spray during the season without using any pre-seasonal medicine. The symptoms and medication score were compared between those two groups. Results) The nasal discharge score of the pre-seasonal medication group decreased dramatically in comparison to the in-seasonal medication group for the first 2 weeks of the pollen season. The symptom medication score of the pre-seasonal medication group was also significantly lower than that of the in-seasonal medication group throughout the pollen season. Conclusion) These data suggest that levocabastine nasal spray might therefore be a useful pre-seasonal drug for patients with Japanese cedar pollinosis.
