Abstract
We treated 12 male and 6 female patients (57.0 years of age on average) with an abnormal sensation in the throat (AST) possibly due to gastroesophageal reflux disease (GERD) with delayed gastric emptying (DGE) and 10 male and 19 female patients (56.9 years of age on average) with AST due to GERD without DGE using an oral proton pump inhibitor (PPI), lansoprazole 15mg/day, for 2 weeks. As a result, a reduction of AST by 50% or more was thus observed in 76% of the patients without DGE, while such an improvement was only seen in 39% of the patients with DGE. A statistically significant difference (p=0.03 by Mann-Whitney U test) was thus observed in the ratio between the two patient groups. Therefore, we recommend the use of some other medications which are expected to improve DGE in combination with PPI for the treatment of patients with AST due to GERD with DGE.
