A CLINICAL AND HISTOPATHOLOGICAL STUDY OF LARYNGEAL CARCINOMA

Abstract

Part I Stromal Reaction
On 150 cases of laryngeal cancer the author studied the conditions that influenced on stromal reaction. The chief results were as follows:
1) In most cases the tumor of the upper parts above the ventricle of the larynx presented thick cell infiltration, but that of the lower parts below the vocal cords had much proliferation of increased connective tissue.
2) As for the tumor of the lower parts below the vocal cords, the one slightly infiltrating into the deep tissue had thick cell infiltration, but as the infiltration advanced, connective tissue was proliferated more closely and infiltrating cells be-came less.
3) Three types of tumor tissues classified by the developing form showed their individual ten-dencies to stromal reactions.
4) It was only recognized in the small range along ulcer that ulcer formation influenced on stromal reaction.
Part II Blood Supply in Cancerous Tissue
The author observed blood supply in experi- mental skin-cancer of mice and in human laryn- geal cancerous tissue, using India ink. Following was obtained results.
1) After epithelial cells began to show can- cerous proliferation in the process of experimental skin-cancer formation, various figures showing ab normal blood flow were recognized in addition to the dilation of the blood vessels that had been formerly observed.
2) The surrounding stroma of human laryngeal cancer presented the same figures above mentioned in experimental skin cancer.