A CLINICO-PATHOLOGICAL STUDY OF SQUAMOUS CELL CARCINOMAS OF THE SINO-NASAL CAVITY METAPLASIA AND DYSPLASIA
1989 Volume 92 Issue 3 Pages 334-346
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1989 Volume 92 Issue 3 Pages 334-346
We report a clinicopathological study in 193 cases with squamous cell carcinoma (SCC) in the sino-nasal cavity.
Squamous metaplasia were found in 62.6% and squamous dysplasia in 25.3% of the SCC cases.
These lesions seem to be important factors related with cancer development.
Etiologically, metaplasia was found too be related with age and sex (male-dominant), but not with smoking and history of sinusitis.
Chronic inflammation, papillary or stratified proliferation and reserved cell hyperplasia were considered as factors inducing squamous metaplasia in review of pathological specimens.
We infered from the distribution pattern of cytokeratin that it might occur serial changes from metaplasia, dysplasia, CIS to microinvasive carcinoma, whose phenomenon was commonly seen in cases of uterus squamous cell carcinoma.
