EVALUATION OF PROLIFERATING ACTIVITY OF PLEOMORPHIC ADENOMA ARISING FROM THE SALIVARY GLANDS -USING ANTI BrdU MONOCLONAL ANTIBODY-

YASUKO URAO

doi:10.3950/jibiinkoka.92.420

YASUKO URAO

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JOURNAL FREE ACCESS

1989 Volume 92 Issue 3 Pages 420-432

DOI https://doi.org/10.3950/jibiinkoka.92.420

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Published: January 20, 1989 Received: - Available on J-STAGE: March 19, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: March 19, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: March 19, 2008 Reason for correction: - Correction: CITATION Details: Wrong : 1) Jhonson HA et al:A radioautographic study of ahuman brain and glioblastoma multiform after thein vivo uptake of tritiated thymidine.Cancer13636-642,1961.
3) Frindel E et al:Cell proliferation kinetics in fivehuman solid tumors.Cancer 22:1011-1035,1969.
5) Hoshino T et al:Cell kinetics of human gliomas.J Neurosurg37:15-26,1972
7) Hoshino T et al:Cell kinetic analysis of humanmalignant brain tumors(Gliomas).Cancer 44:956-962,1979.
8) Hoshino T et al:Radiosensitizasion of malignantbrain tumors with bromodeoxyuridine.ActaRadiol Ther Phys Biol 8:15-16,1969.
10) Granzner H:Monoclonal antibody to 5-bromo and5-iodedeoxyuridine.Science218:474-475,1982.
11) Phillip ND:Cellcycle analysis using a monoclonalantibody to BrdUrd.Cell Tissue Kinet 17:427-436,1984.
14) Wilson GD et al:The Labelling Index of Humanand Mouse Tumors Assessed by Bromodeoxyuridine Staining In Vitro and In Vivo and FlowCytometry.Cytometry 6:641-647,1985.
16) Langer EM et al:Cycling Sphase cells in animaland spontaneous tumors.Acta Radiolodica Oncology 24,545-548,1985.
23) Hosino T et al:Cell kinetic studies of in situ humanbrain tumors with Bromodeoxyuridine.Cytometory 6:627-632,1985.
26) Nagasima T et al:The proliferative potential ofhuman pituitary tumors in situ,J Nourosurg 64:588-593,1986.
27) Murovic JA et al:Pediatric Central Nervous System Tumors.A Cell kinetic Study withBromodeoxyuridine.Neurosurg 19:900-904,1986.
28) Hoshino T:In situ kinetics studies on human neuroectodermal tumors with bromodeoxyuridine labeling.J Neurosurg 64:453-459,1986.
30) Hosino T et al:Proliferative potential of humanmeningioma of the brain.Cancer 58:1466-1472,1986.
31) Franco MM:Cell Kinetiac Studies in Patients withLung Cancer.Oncology 30:353-361,1974.
32) Sasaki K:Measurement at Tritiated ThymidineLabeling Index by Incubation in vitro of SurgicallyRemoved Cervical Cancer.Gann 68:307-313,1977.
33) Sasaki K et al:Immunological determination oflabeling index on human tumor tissue sections usingmonoclonal anti-BrdUrd antibody.Stain technology61:155-161,1986.
34) Sasaki K et al:Anautaradiographic study on thelabeling index of biopsy specimens from gastriccancers.Cancer 54:1307-1309,1984.
35) Michael N:Cell Cycle Kinetic Measurements in anIrradiated Rat Rhabdomyosarcoma Using a Monoaclonal Antibody to Bromodeoxyuridine.Cytometry 6:611-619,1985.
36) Tada T et al:Immuno histochemical cell kineticstudy of human lung cancer by using monoclonalantibody to Bromodeoxyuridine.Jpn J CIin Oncol16:129-135,1986.
38) Risio M:Immunohistochemical Study of EpithelialCell Proliferation in Hyperplastic Polyps,Adenomas,and Adenocarcinomas of the LargeBowel.Gastroenterology 94:899-906,1988.

Right : 1) Jhonson HA et al:A radioautographic study of ahuman brain and glioblastoma multiform after thein vivo uptake of tritiated thymidine.Cancer13636-642,1961.
3) Frindel E et al:Cell proliferation kinetics in fivehuman solid tumors.Cancer 22:1011-1035,1969.
5) Hoshino T et al:Cell kinetics of human gliomas.J Neurosurg37:15-26,1972
7) Hoshino T et al:Cell kinetic analysis of humanmalignant brain tumors(Gliomas).Cancer 44:956-962,1979.
8) Hoshino T et al:Radiosensitizasion of malignantbrain tumors with bromodeoxyuridine.ActaRadiol Ther Phys Biol 8:15-16,1969.
10) Granzner H: Monoclonal antibody to 5-bromo and 5-iodedeoxyuridine. Science218 : 474-475, 1982.
11) Phillip ND:Cellcycle analysis using a monoclonalantibody to BrdUrd.Cell Tissue Kinet 17:427-436,1984.
14) Wilson GD et al:The Labelling Index of Humanand Mouse Tumors Assessed by Bromodeoxyuridine Staining In Vitro and In Vivo and FlowCytometry.Cytometry 6:641-647,1985.
16) Langer EM et al:Cycling Sphase cells in animaland spontaneous tumors.Acta Radiolodica Oncology 24,545-548,1985.
23) Hosino T et al:Cell kinetic studies of in situ humanbrain tumors with Bromodeoxyuridine.Cytometory 6:627-632,1985.
26) Nagasima T et al:The proliferative potential ofhuman pituitary tumors in situ,J Nourosurg 64:588-593,1986.
27) Murovic JA et al:Pediatric Central Nervous System Tumors.A Cell kinetic Study withBromodeoxyuridine.Neurosurg 19:900-904,1986.
28) Hoshino T:In situ kinetics studies on human neuroectodermal tumors with bromodeoxyuridine labeling.J Neurosurg 64:453-459,1986.
30) Hosino T et al:Proliferative potential of humanmeningioma of the brain.Cancer 58:1466-1472,1986.
31) Franco MM:Cell Kinetiac Studies in Patients withLung Cancer.Oncology 30:353-361,1974.
32) Sasaki K:Measurement at Tritiated ThymidineLabeling Index by Incubation in vitro of SurgicallyRemoved Cervical Cancer.Gann 68:307-313,1977.
33) Sasaki K et al:Immunological determination oflabeling index on human tumor tissue sections usingmonoclonal anti-BrdUrd antibody.Stain technology61:155-161,1986.
34) Sasaki K et al:Anautaradiographic study on thelabeling index of biopsy specimens from gastriccancers.Cancer 54:1307-1309,1984.
35) Michael N:Cell Cycle Kinetic Measurements in anIrradiated Rat Rhabdomyosarcoma Using a Monoaclonal Antibody to Bromodeoxyuridine.Cytometry 6:611-619,1985.
36) Tada T et al:Immuno histochemical cell kineticstudy of human lung cancer by using monoclonalantibody to Bromodeoxyuridine.Jpn J CIin Oncol16:129-135,1986.
38) Risio M:Immunohistochemical Study of EpithelialCell Proliferation in Hyperplastic Polyps,Adenomas,and Adenocarcinomas of the LargeBowel.Gastroenterology 94:899-906,1988.

Date of correction: March 19, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Salivary gland tumors present diverse histopathological aspects and show various biological behavior. At present, the immunohistological method using anti-BrdU monoclonal antibodies, which was originated in the field neurosurgery, has been tried extensively in various fields of medicine. Using this method, the authors have attempted to detect biological characteristics of salivary gland tumor tissues, especially those of pleomorphic adenomas. The lab0elling index (L. I.) is defined as the percentage of the labelled cells (proliferating cells) in the tumor tissue. In order to confirm the usefulness of the L.I. for measuring the proliferating activity of tumor tissue, an investigation was conducted with respect to squamous cell carcinomas of the head and neck, excluding salivary gland tumors. The results indicate that the L.I. is highly correlated with the differentiation of these carcinomas. In salivary gland tumors, values of the L.I. are also higher for benign tumors than for normal or inflammating tissues and the values were even higher for malignant tumors. Values of the L.I. are low for pleomorphic adenomas, which are the majority of salivary gland tumors, as well as for other benign tumors. However considerable individual variabilities, are bound for pleom. ad. and the values of the L.I. are markedly high in some cases.
These high values are particularly common in patients with whom strong positivity in Ga scintigraphy, or primary growth in the submandibular glands are found. The localization of proliferating cells shows a characteristic pattern in each type of tumor tissue. In pleomorphic adenomas, proliferating cells are sporadically distributed but the main growth is located at the site of the epithelioid proliferative region, excluding the duct-forming locus. However, the overall proliferating activity of myxochondromatous tumors is not generally low, and the proliferating activity is not particularly high in the region of infiltrating is the capsule.

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