スギ花粉症におけるオロパタジン塩酸塩経口薬・点眼薬併用療法の有用性

抄録

Japanese cedar pollinosis is the most common seasonal rhinoconjunctivitis in Japan. Nasal and ocular symptoms often interact with each other, however, the nose and eyes are often treated independently, and their responses to treatment are also evaluated independently in many cases.
This study was designed to assess the efficacy of combined administration of the oral and ophthalmic formulations of antihistamine olopatadine hydrochloride, when administration was started before pollen season or after the onset of symptoms. Patients who received pre-season treatment had significantly lower scores for the following outcome measures than those who began olopatadine therapy after allergic symptoms appeared: nasal congestion, nasal discharge, total nasal symptom score, and itchy eyes. Even starting oral and ophthalmic olopatadine after the onset of symptoms resulted in a significant improvement in all nasal and ocular manifestations within two days. These findings suggest that the comprehensive treatment of the nose and eyes with a combination of oral and ophthalmic olopatadine is extremely beneficial in patients with Japanese cedar pollinosis. Although this therapy provides immediate symptomatic relief, it is recommended to start both formulations before pollen season.