TS-1® is an oral anticancer drug composed of tegafur which is a derivative of 5FU and 5-chloro-2,4-dihydroxypyridine (CDHP) and oxonic acid. We report on a patient with acute toxicosis who orally ingested a large dose of TS-1® 1400 mg in an effort to commit suicide.
First of all, we treated him with gastric lavage, laxative and hydration. After that, he underwent hemodialysis. Before hemodialysis the blood concentration of tegafur was 25200 ng/mL, 5-FU was 3000 ng/mL and CDHP was 1870 ng/mL. These blood concentrations were high, compared with cases where 50 mg of TS-1® has been ingested. After the 2nd hemodialysis, all blood concentrations decreased to the normal level, so the patient was saved without severe side effects. To our knowledge, there has been no report of a case involving ingestion of a large dose of TS-1®, and we therefore report our experience of this rare case.
