Treatment targeting the androgen receptor and HER-2/neu of salivary duct carcinoma has recently attracted attention, however we have encountered a patient who was double negative for androgen receptor and HER-2/neu. The patient was a 78-year-old man. Skin metastasis and cervical lymph node recurrence were noted at six months after surgery. HER-2/neu and the androgen receptor in the surgical specimen were both negative. There was no metastasis at any other site. Irradiation at 50 Gy and of DOC 35 mg/m2 every two weeks were administered. The results showed complete response. There have been an only a few reports in which CR with chemoradiation for recurrent salivary gland duct carcinoma has been achieved. In addition, neck recurrence was noted in the present case at 11 months after CR, but showed a good reaction with re-administration of the DOC. Chemoradiotherapy and chemotherapy including taxanes may be an option in treatment of double-negative cases.
