Fisher syndrome is characterized by the clinical triad of ophthalmoplegia, ataxia, and areflexia. It is considered as a variant form of Guillain-Barré syndrome, which is associated with anti-ganglioside antibodies.
Herein, we report two cases of Fisher syndrome. Case 1 was a 49-year-old man. He presented with the complaint of double vision 7 days after the onset of symptoms of an acute upper respiratory infection. Computed tomography revealed sinusitis in the sphenoid sinus. Subsequently, the patient developed abducens nerve palsy and loss of tendon reflexes in the lower limbs. Case 2 was a 48-year-old man. The patient presented with the complaint of dizziness 10 days after the onset of a fever. Subsequently, the patient developed disturbance of the upward, downward and inward ocular movements. Because in both cases, external ophthalmoplegia appeared after a upper respiratory infection, we checked for the presence of anti-ganglioside antibody in the serum. As Case 1 was positive for anti GT1a antibody and Case 2 for anti GQ1b antibody, both were diagnosed as having Fisher syndrome. Both cases recovered spontaneously within 2–4 months.
