Mammary analogue secretory carcinoma (MASC) is a malignant salivary gland tumor that was first described by Skálová et al. in 2010. Before that MASC was histologically misclassified as acinic cell carcinoma, adenocarcinoma not otherwise specified, or cystadenocarcinoma. Herein, we report the case of a 47-year-old man with MASC of the left salivary gland. The patient was initially diagnosed, by preoperative fine needle aspiration cytology, as a case of acinic cell carcinoma; however, postoperative histopathology and immunohistochemistry revealed that the diagnosis of MASC.
The carcinoma was further diagnosed as an intermediate-grade salivary gland carcinoma, and the patient received radiotherapy as additional postoperative treatment. Following this treatment, no recurrence or metastasis was detected until the last follow-up. MASK is known to carry genetic translocation, the NTRK mutation. Selective targeting of this mutation could be the ideal way to treat this cancer.
