Abstract
The influences of kanamycin upon the inner ear, brain and kidney were studied in the guinea pig and the following results were obtained.
The control experiments have revealed that the drug did not easily pass into the inner ear, brain, and boundary zone and medullary substances of the kidney. But after prolonged use of the drug it might appear in these organ and tissues. For instance, both the stria vascularis and spiral ligament (lower portion) revealed definite increase in permeability.
The changes in permeability was seemed to precede to changes in alteration of glucose metabolism, as the glucose metabolism of the stria vascular is and spiral ligament was not inhibited under the present experimental conditions.
