On the basis of biochemical and clinical examinations, the new therapeutic measure of sudden deafness has been presented according to an assumption that a large proportion of sudden deafness was due to impairment of the inner ear caused by abnormal blood circulation.
From January through October in 1963, 34 cases were treated with special importance on the following points: (1) improvement of the inner ear blood circulation, (2) activation of oxidative phosphorylation (by means of an intravenous injection of ATP in large amount) and (3) activation of general metabolism.
The results of the above series were compared with thoses of 59 cases treated in the preceding 10 years by the combined use of vasodilators and vitamin B complexes.
(1) The new treatment produced a marked effect in 61% of fresh cases and in 71% of sub-fresh cases, while the old treatment only 37% and 35% in each category. Neither method was effective in cases older than 14 days.
(2) In cases of total hearing loss, the old treatment produced effect in less than 10% of the cases, while the new treatment raised the efficacy to 40%. However no one patient made a perfect recovery.
(3) The presence of vestibular symptom produced no significant difference between the effect of both methods.
Relationship between the results of audiometrical examinations and the effect of the new treatment:
(1) Observing their hearing curve and prognosis, it was found that the prognosis of cases with slope fall at low frequency and flat curve was relatively good, whereas those with steep fall at high frequency had the worst prognosis.
(2) In regard to hearing recovery process, cases making an even recovery over total frequency were observed most often. Generally however, the recovery in high frequency was not good.
(3) There were 2 cases of spontaneous recovery among 34 cases. Both of them made a remarkable recovery in low frequency.
The relationship between the results of clinical examinations and the effect of the new treatment:
(1) In cases where inner ear hemorrhage was suspected the new method gave negligible benefit.
(2) The new treatment was relatively effective in cases of hypo-tension. A mildly positive virological test was found in one of 8 fresh cases.

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Treatment of vascular disorder with cytochrome C has been reported in the fields of neurosurgery and internal medicine. But it is unknown wheather the drug might be effective to otological disease with deafness and/or vestibular symptom.
The authors would describe three cases, to which intravenous injections of cytochrome C were effective. The first one was sudden deafness, the second one progressive deafness and the last one head injury.
Definite improvement of hearing was achieved in all cases after injections. The case of head injury had both atypical alternating spontaneous nystagmus and unilateral optokinetic nystagmus inversion. But both symptoms have disappeared by injections. The cause of improvement of the symptoms is still unknown.

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Three cases of dermoid cyst at the floor of the mouth were reported. In one case, the tumor was located in the left side, the others were in the middle of the mouth.
In two cases a submandibular incision was needed at the extirpation of the cysts, but one of these cysts was removed perorally without the submandibular incision.
Histologically, one of these cysts was proved to be the epidermoid cyst and the others were dermoid cysts with sebaceous glands.

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Recently experienced seven cases of socalled associated laryngeal paralysis were reported. They were 4 unilateral paralysis, 2 mixed bilateral paralysis and a bilateral paralysis.
With the electromyographic examinations for 3 cases of them, it was investigated for the cases to be in the condition of paresis and to show various and complicated muscle action potential in the abnormal forms in spite of accompanying with the fixations of the vocal cords.
Moreover, the questions of the laryngoscopic findings in the vocal cordparalysis were alluded to: especially on the fixed position of the paralysed vocal cord and the strange change of the arytenoid region at the paralytic side.

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Thirty patients in E. N. T. Clinic of Kyoto University, complaining of hyperrhinorrhea, nasal obstruction, hyposmia and other nasopharyngeal symptoms were treated with peroral administration of EMPYNASE capsules, a kind of anti-inflammatory proteolytic enzyme. The marked effect for subjective complaints was recognized in 23% of the cases, good effect in 40%, poor result in 37% and no apparent side effect was observed in the all cases.
The authors concluded that EMPYNASE was available for a pharmacotherapy of chronic rhinitis and paranasal sinusitis.

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Otorhinolaryngologic Section of Japanese National Railway Hospital Osaka
Fourty-four patients suffered from chronic sinusitis were treated by application of Empynase, Kimopsin and Varidase Buccal.
The differences of the effect of these drugs were compared wit heach other.
In our clinical observation, the effect of Kimopsin were controlled by the effect of antibiotics.
As the results, clinical symptoms were improved in 71% of Empynase group, in 40% of Kimopsin group and in 0% of Varidase Buccal group.
It has been considerd that the interesting effect of these drugs upon the symptoms of chronic sinusitis should not be expected by only use of these.

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The upper part of the sac of cyst was exposed from the overlying tisse us and opening the cavity and treating it with crystal violet were done.
The cystic walls exposed were holded in block by a hemostat to facilitate to retract the cyst to any side. And the tissues around the sac were push away against it, not touching the sac itself. Then complete removing ranula could be done successfully.

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The influences of kanamycin upon the inner ear, brain and kidney were studied in the guinea pig and the following results were obtained.
The control experiments have revealed that the drug did not easily pass into the inner ear, brain, and boundary zone and medullary substances of the kidney. But after prolonged use of the drug it might appear in these organ and tissues. For instance, both the stria vascularis and spiral ligament (lower portion) revealed definite increase in permeability.
The changes in permeability was seemed to precede to changes in alteration of glucose metabolism, as the glucose metabolism of the stria vascular is and spiral ligament was not inhibited under the present experimental conditions.

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