Abstract
Eight patients with maxillary cancer had Adriamycin patched in the maxillary sinus and OK-432 locally injected into the tumor tissue. As a result, remarkable reduction of the cancer was recognized.
Twenty-four hours and 48 hours after Adriamycin patching, the Adriamycin concentration in the blood and in the tumor tissue were measured. The transition to the blood was low, whereas the transition to the tissue was high.
Side effects of fever and edema of the face were observed, but these disappeared quickly and were not serious.
