Acute suppurative thyroiditis is one of the thyroid inflammatory diseases and is a rare condition. The pathogenesis was usually uncertain, until Miyauchi et al. emphasized the significance of the internal fistula originating from the apex of the left piriform sinus as the route of infection to the thyroide. We describe here a case of repeated suppurative thyroiditis in a 17-year-old female with a piriform sinus fistula. The infection may spread to the thyroid through this fistula. Infection through a fistula of the piriform sinus is the most important cause of suppurative thyroiditis. Therefore, a barium study is necessary. Hemithyroidectomy was done, taking care to follow the fistula tract and remove the fistula completely to avoid recurrence.