UFT投与上顎癌例の血中・組織内5-FU濃度
1988 年 81 巻 10 号 p. 1521-1525
詳細
1988 年 81 巻 10 号 p. 1521-1525
5-FU and FT-207 concentrations in serum and tumor tissues of four patients with maxillary cancers were measured after treatment with UFT.
1. Initial concentrations of 5-FU in tumor tissues after the administration of UFT (600mg 3 days) were at least 0.05mcg/g, a satisfactory level.
2. Levels of FT-207 in tumor tissue were consistently lower than in the serum, while levels of 5-FU in tumors were about 2-5 times higher than in the serum.
3. 5-FU concentrations in three patients continued to be more than. 0.05mcg/g at 8 hours and were highest at 1 4 hours, indicating that a dose of 600mg/day of UFT maintained effective concentrations.
When combined with radiation therapy and local necrotomy, UFT appears to be an effective anticancer agent for maxillary cancer.
