Clinical Experience with OFLX in Patients with Chronic Sinusitis Being Treated with Maxillary Tube

Abstract

We studied the effects of OFLX in 21 patients with chronic sinusitis with bacteria cultured from their maxillary sinuses.
OFLX was administered at a dose of 600mg/day for 3 weeks, and clinical and bacteriological examinations were performed. Maxillary tube therapy was also used.
The rate of cure of infections with positive or gram negative aerobes was 77%, and if anaerobes were present this rate became 85%. The penetration of OFLX into the maxillary membrane was good, and it's concentration was there equal to or higher than the blood level. It is concluded that since OFLX has a broad antibacterial spectrum and good transfer to the sinus membranes, it is an effective drug for treating chronic sinusitis.