Effect of Combined Use of Sulpiride and Tiaramide HCl on Abnormal Sensation in the Throat

Abstract

The majority of patients with abnormal sensation in the thoat have a history of an upper respiratory tract infection, increased apprehension, cancerphobia, depression, etc. Therapy of such patients with an anti-depressant plus an anti-inflammatory agent is expected to be effective.
The authors administered Sulpiride (150mg/day) and Tiaramide HCl (300mg/day) for two weeks to 114 patients with abnormal sensation in the thoat and evaluated the results. Side effects, such as abdominal symptoms, drowziness or headache, were reported by 9 patients (8%) including 3 patients in whom the medication had to be suspended. The therapeutic effect of the medication was evaluated in the remaining 111 patients at the end of the first and second week of administration and one week after the termination of treatment. It was considered to be effective when the abnormal sensation improved subjectively by 50% or more. The combined therapy was effective in 56% of the 111 patients within one week, in 72% in two weeks and in 73% in three weeks. The therapy was more effective in patients with depressive state and/or mild inflammation in the throat.