Cystic diseases such as dermoid cyst, epidermoid cyst, ranula and thyroglossal cyst are often found in the floor of the mouth. We report two cases of large epidermoid cyst which developed in adults. Magnetic resonance imaging (MRI) clearly demonstrated the location and cystic features of the tumor in the second case, which was not diagnosed by other examinations. We concluded that MRI is of great benefit in the diagnosis of lesions of the head and neck.